重复剂量米索前列醇用于早孕药物流产的探讨  

The Effect of Repeated Dose of Misopristol on the Early Medical Abortion

作　　者：陈金虹[1] 方爱华[1] 陈勤芳[1] 

机构地区：[1]上海交通大学医学院附属国际和平妇幼保健院,上海200030

出　　处：《中国临床医学》2008年第4期528-529,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:探讨米非司酮配伍米索前列醇终止早孕时,增加米索前列醇的用药次数,能否提高药物流产成功率。方法:采用单、双日的半随机法,把符合药物流产条件而准备终止早孕的健康孕妇随机分为研究组和对照组。研究组在给常规方法治疗的基础上加服0.6mg米索前列醇。对照组则按国内药流常规方法。比较两组孕妇在留院观察期内孕囊排出成功率以及总的药物流产成功率。结果:在留院观察期内研究组的孕囊排出率为77.5%,对照组为69.4%,差异无统计学意义。研究组的完全流产率为98.0%,明显高于对照组(P=0.042)。结论:应用米非司酮配伍米索前列醇终止早孕时,如在药物流产第3天增加1次米索前列醇的剂量则可以提高药物流产成功率。Objective：The aim of this study was to investigate whether giving more dose of misoprostol would improve the complete success of medical abortion on early pregnancy. Methods： Hal-randomized study was used when distribute the group. Women in the control group received mifepristone total 150mg in three days and misoprostol 0.6mg on the third day. Women in the studied group received another more misoprotol 0.6mg in 4 hours later when they took routine medicines for abortion. The success rate of passed gestation sac during watching period in hospital and complete abortion rate was compared. Results： There was 77.5% women passed their gestation sac during watching period in hospital, while there was only 69.4% in the control group. But no statistical significance was founel. The complete success rate of medical abortion was 98.0% in study group,and 93.2% in the control group. There was a significant difference between the two groups, P=0.042. Conclusion： Giving more dose of misoprostol on the third day would improve the success rate of medical abortion for early pregnancy women.

关 键 词：重复剂量 米索前列醇 药物流产 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]