丹芪益肝颗粒对慢性肝损伤大鼠的肝保护作用  

Protective Effect of Danqi Yigan Granule on the Liver Chroically Injured by Carbon Tetrachloride in Rats

作　　者：蔡大伟[1] 刘顺良[1] 尹晓飞[1] 李冬梅[1] 王书杰[1] 史宇翔[1] 李慧[1] 

机构地区：[1]解放军第251医院药剂科,河北张家口075000

出　　处：《医药导报》2008年第9期1028-1030,共3页Herald of Medicine

摘　　要：目的验证丹芪益肝颗粒对四氯化碳(CCl4)所致大鼠慢性肝纤维化模型的肝保护作用及抗纤维化作用。方法模型组及各给药组首次皮下注射40%CCl45 mL.kg-1,以后每3 d注射1次40%CCl43 mL.kg-1,正常对照组给予等容积橄榄油,持续9周,给药自造模之日开始。结果CCl4所致慢性肝纤维化大鼠有明显肝损伤及慢性纤维化表现,丹芪益肝颗粒3个剂量组肝功能指标均有不同程度的改善;5,10 g.kg-1组肝组织胶原蛋白含量较模型组均明显降低;2.5 g.kg-1组血清玻璃酸(HA)较模型组显著降低;病理组织学检查结果表明其肝脏病变程度均较模型组明显减轻。结论丹芪益肝颗粒对慢性肝纤维化大鼠具有肝保护作用及抗肝纤维化作用。Objective To validate the protective role of danqi yigan granule in antagonizing chronic fibrosis of rats liver caused by carbon tetrachloride（CC14）. Methods Hepatic fibrosis was induced via hypodermic injection of 40% CC14 （5 mL for the first time ,3 mL per 3 days） for 9 weeks. The control group was treated by olive oil. Danqi yigan granule was administered at a dose of 2.5, 5 or 10 g · kg^-1. Results Obvious liver damage and chronic fibrosis were observed in the CC14 group. The liver function were improved in three doses threatment of danqi yigan granule. Collagen in the liver tissue markedly declined at a dose of 5 or 10 g · kg^-1, and serum hyaluronic acid also decreased obviously at a dose of 2.5 g · kg^-1. Furthermore, the histopathological lesion was significantly allayed in ruangan granule groups. Conclusion Danqi yigan granule played an important role in preventing chronic fibrosis of rat liver.

关 键 词：丹芪益肝颗粒 四氯化碳 肝纤维化 

分 类 号：R286[医药卫生—中药学] R975.5[医药卫生—中医学]