疏水性L-酒石酸酯/羟丙基-β-环糊精分离体系分离反式第一菊酸对映体  

Enantioselective Extraction of trans-Chrysanthemic Acid Enantiomers in Separation System Containing Lipophilic L-tartaric Esters and Hydroxypropyl-β-cyclodextrin

作　　者：易健民[1] 陈立根[2] 潘春跃[2] 唐课文[1] 

机构地区：[1]湖南理工学院化学化工系,岳阳414000 [2]中南大学化学化工学院,长沙410083

出　　处：《应用化学》2008年第9期1027-1031,共5页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金资助项目(20676028)

摘　　要：以疏水性L-酒石酸酯和羟丙基-β-环糊精(HP-β-CD)为手性选择剂,建立反式第一菊酸对映体(trans-CA)的萃取分离方法,研究了反式第一菊酸对映体在含有酒石酸酯的1,2二氯乙烷溶液及含有环糊精的甲醇水溶液两相中的萃取分配行为;考察了L-酒石酸酯浓度、羟丙基-β-环糊精的浓度、L-酒石酸酯烷基链长度、水相pH值和溶解反式第一菊酸的甲醇水溶液浓度等因素对萃取分离效果的影响。实验结果表明,L-酒石酸酯与S对映体形成的复合物稳定性比R对映体形成的复合物要好;随着L-酒石酸酯浓度的增大,分配系数K和分离因子α均增大;羟丙基-β-环糊精的浓度增大,K和α先增大而后减小,在其浓度为3 mmol/L时达最大值;L-酒石酸酯烷基链长度对K和α有较大影响;pH值增大,K和α均降低;甲醇水溶液中甲醇体积分数增大,K和α均减小,当甲醇体积分数为10%时,得到最大K和α。To establish an extraction method for trans-chrysanthemic acid using lipophilic L-tartaric esters and hydroxypropyl-β-cyclodextrin as chiral selector, the distribution of trans-CA enantiomers was examined in aqueous methanol solution containing HP-β-CD, 1,2-dichloroethane organic solution and lipophilic L-tartaric esters. The influences of the concentrations of L-tartaric esters and HP-β-CD, the length of alkyl chain of L-tartaric esters, pH and the concentration of aqueous methanol solution on the partition coefficient（K） and separation factor（α） of trans-CA were investigated. The experiment results show that the complex formed by L-tartaric esters with S enantiomers is stabler than that by L-tartaric ester with R enantiomers. With the increase of the concentration of L-tartaric esters, K and α increased; with the increase of the concentration of HP-β-CD, K and α increased firstly, and then decreased, K and α were the highest when the concentration of HP-β-CD was 3 mmol/L. The length of alkyl chain of L-tartaric esters has great influences on K and α. With the increase of pH, K and α decreased; with further increasing the concentration of methanol, K and α decreased, K and α were the highest when the concentration of methanol was 10%.

关 键 词：手性拆分 酒石酸酯 羟丙基-Β-环糊精 反式第一菊酸 

分 类 号：O652.6[理学—分析化学]