乌司他丁治疗吸入性损伤的临床观察  

Clinical study of ulinastatin for treating inhalation injury

作　　者：李全[1] 刘群[2] 李林[2] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津市第四医院烧伤科

出　　处：《天津医科大学学报》2008年第3期285-287,318,共4页Journal of Tianjin Medical University

基　　金：天津市卫生局科技基金攻关项目(06KG06)

摘　　要：目的:观察乌司他丁对吸入性损伤后患者肺功能改善和支气管黏膜愈合情况的影响。方法:分别设乌司他丁治疗组和对照组各16例,治疗组每次给予乌司他丁10万单位,每天3次,连续静脉点滴10日。观察两组治疗前后呼吸频率(RR)、氧合指数、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2),以纤维支气管镜形态学观察两组气管黏膜愈合情况,评估支气管黏膜愈合时间。记录两组患者肺感染发生率。结果:与对照组比,治疗组患者RR、氧合指数、PaO2均有显著改善,支气管黏膜愈合时间缩短,肺感染发生率无显著性差异。结论:乌司他丁有助于改善吸入性损伤患者的氧合功能和支气管黏膜愈合,对吸入性损伤有一定的治疗作用。Objective： To observe the effect of ulinastatin on pulmonary system and treatment period of patients＇ bronchial mucosa with inhalation injury. Methods： 32 patients with inhalation injuries were divided into treated group and control group. 16 patients in treated group were treated with ulinastatin 100 000 units by intravenous drip, three times a day for 10 days. The respiration rate, PaO2/FiO2, PaO2, PaCO2 were checked at the start and end of the experiment. The bronchial mucosa was also checked with the fiber-optic bronchoscope .The pulmonary infection rates of the treated group and control group were recorded. Results： The respiration rate, PaO2/FiO2, PaO2 of patients in treated group were found to be comparatively superior to the patients in the control group, indicating an improvement. The bronchial mucosa of patients in treated group was found to be in better condition than the patients in the control group, indicating a decrease of healing time.There was no significant difference bewteen two groups of pulmonary infection rates. Conclusion： Ulinastatin is helpful in increasing oxygenation index. It is also successful in decreasing the treatment period of injured bronchial mucosa.

关 键 词：吸入性损伤 乌司他丁 纤维支气管镜 

分 类 号：R644[医药卫生—外科学] R56[医药卫生—临床医学]