由α-异佛尔酮催化合成3,5,5-三甲基-1,2-环己二酮的研究  

Catalytic Synthesis of 3,5,5-Trimethyl-1,2-cyclohexanedione from Rearrangment and Oxidation of α-Isophorone

作　　者：钟文周[1] 邢孔强[1] 尹笃林[1] 王季惠[1] 毛丽秋[1] 

机构地区：[1]湖南师范大学精细催化合成研究所,湖南长沙410081

出　　处：《精细化工中间体》2008年第4期38-40,共3页Fine Chemical Intermediates

基　　金：国家自然科学基金资助项目(20572021);湖南师范大学青年基金资助科研项目(070643)

摘　　要：以α-异佛尔酮为原料,经过碱性条件下过氧化氢环氧化和固体酸催化重排合成3,5,5-三甲基-1,2-环己二酮。考察了反应温度、反应时间、反应溶剂对重排反应的影响。优化条件为:以无水氯化锌作催化剂,二氯甲烷作溶剂,回流反应30min,2,3-环氧异佛尔酮于回流温度下可完全转化,产物的选择性达87.4%。3,5,5 -Trimethy1-1,2 -cyclohexanedione was synthesized from α-isophorone through epoxidation under alkaline condition and rearrangment catalyzed by solid acid. The influence of reaction temperature, reaction time and reaction solvent on the rearrangment was investigated. It is found that 2,3-epoxyisophorone can be converted under the mild condition. The selectivity of 3,5,5-trimethyl-1,2-cyclohexanedione was 87.4% from the rearrangment of the epoxides catalyzed by zinc chloride in CHECl2 reflux for 30 min.

关 键 词：催化 α-异佛尔酮 3 5 5-三甲基-1 2-环已二酮 

分 类 号：O643.32[理学—物理化学]