两种新型卟啉-5-氟尿嘧啶化合物的合成  

Synthesis of Two Novel Porphyrin-5-fluorouracil Compounds

作　　者：李雅[1] 李淑贤[2] 韩士田[1] 刘彦钦[1] 

机构地区：[1]河北师范大学化学与材料科学学院,河北石家庄050016 [2]河北邯郸学院化学系,河北邯郸056005

出　　处：《河北大学学报（自然科学版）》2008年第4期395-398,共4页Journal of Hebei University(Natural Science Edition)

基　　金：河北省自然科学基金资助项目(203147)

摘　　要：以对羟基苯甲醛、茴香醛为主要原料,合成了2种新型卟啉-5-氟尿嘧啶化合物,并通过红外光谱、紫外光谱、核磁共振氢谱、碳谱和电喷雾质谱测试技术对化合物结构和组成进行了确认.探索了目标化合物的合成及分离纯化的条件.选择非质子极性溶剂DMF为反应溶剂,反应温度为120℃,TLC检测反应的进行,大约10 h反应完全,反应收率为49.0%-50.6%.采用薄层层析硅胶G作固定相,以V（氯仿）∶V（丙酮）=15∶1作洗脱剂,可得到较好的分离效果.Two novel porphyrin-5-fluorouracil compounds were synthesized with p-hydroxybenzaldehyde and p-anisaldehyde as raw materials. Their structures were confirmed by IR, UV-Vis, ^1H NMR, ^13C NMR and ESIMS, and the conditions of synthesis and separation of the target compounds were explored. The reaction was roughly completed after 10h in yield of 49.0 96 - 50.6 96 via TLC with polar aprotic solvent DMF when temperature was 120 ℃. Better separation effect can be obtained using the thin layer chromatography with silica gel G as stationary phase and chloroform-acctone（15：1, V/V） as eluent.

关 键 词：5-氟尿嘧啶化合物 合成 卟啉 

分 类 号：O626[理学—有机化学]