成人先天性心脏病介入封堵术前后炎症细胞因子的变化  

Inflammatory factor variation pre-and post-intervention in adults with congenital heart diseases

作　　者：李科慧[1] 伍伟锋[1] 刘唐威[1] 

机构地区：[1]广西医科大学第一附属医院心内科,南宁530021

出　　处：《临床心血管病杂志》2008年第7期503-505,共3页Journal of Clinical Cardiology

基　　金：广西科技攻关项目(桂科攻No:0472002-30)

摘　　要：目的:观察成人先天性心脏病(简称先心病)介入封堵术前后炎症细胞因子的变化,探讨介入封堵术对成人先心病免疫激活状况的影响。方法:选择55例成人先心病患者(先心病组),其中40例行介入封堵术;30例年龄及性别与之相匹配的正常体检成人作为对照组。用酶联免疫吸附法(ELISA),检测对照组及先心病组介入封堵术前和术后3、6个月血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及IL-10的动态变化。结果:先心病组术前血清TNF-α、IL-6及IL-10显著高于对照组(均P<0.01),TNF-α/IL-10升高更明显(P<0.01);先心病随着心功能级别增高,血清TNF-α及IL-6水平明显增高(均P<0.05),IL-10水平明显降低(P<0.05);介入封堵术后3个月血清所测细胞因子均明显降低(均P<0.01),至6个月恢复至正常水平。结论:成人先心病存在着一定程度的免疫激活,致使炎性细胞因子增加和抗炎性细胞因子相对不足,并与疾病的严重性关系密切。介入封堵术后免疫系统逐渐恢复平衡。Objective： To explore whether immune activation exists in adults with congenital heart disease （CHD）. Method：Concentrations of tumor necrosis factor （TNF）-α, interleukin-6 （IL-6） and interleukin-10 （IL- 10） were determined by ELISA in 55 adults with CHD and were retested at 3 months and 6 months after interventional therapy in 40 cases of them. 30 healthy adults with age and sex matched were enrolled as controls. Result：Adults with CHD had higher levels of TNF-α, IL-6 and IL-10 （P〈0.01）, compared with normal controls. TNF- α/ IL-10 increased more significantly （P〈0.01）. TNF-α and IL-6 levels were higher in patients with worse heart function according to New York Heart Association Class （P〈0.05）. The level of IL-10 was lower in patients with worse heart function （P〈0.05）. The immune activation gradually returned to normal after interventional therapy. Conclusion：Immune activation exists in adults with CHD, which is dependent on symptom severity.

关 键 词：先天性心脏病 成人 导管封堵术 细胞因子 

分 类 号：R541.1[医药卫生—心血管疾病]