慢性丙型肝炎病毒感染者体内抗第一高变区抗体的变化规律  

Antibody response to hypervariable region 1 in chronic hepatitis C virus infection

作　　者：修冰水[1] 王国华[1] 张贺秋[1] 凌世淦[1] 宋晓国[1] 陈坤[1] 柴文菡[1] 冯晓燕[1] 何竞[1] 朱翠霞[1] 邱艳[2] 王袆[2] 高波[2] 查袆[2] 

机构地区：[1]军事医学科学院基础医学研究所,北京100850 [2]北京红十字血液中心,北京100088

出　　处：《军事医学科学院院刊》2008年第4期332-334,共3页Bulletin of the Academy of Military Medical Sciences

基　　金：国家自然科学基金(30500476);国家“863”重大项目(2006AA02090804);北京市自然科学基金(7082048)

摘　　要：目的:研究丙型肝炎病毒(HCV)感染者在慢性致病过程中抗HVR1抗体的变化规律。方法:分别利用融合HVR1抗原和多靶点HVR1抗原组合包被酶联板,采用间接酶联免疫法,检测不同阶段慢性HCV感染者体内HVR1抗体存在情况及HVR1抗体的异质程度。结果:在42份无临床症状、41份慢性肝病变、38份肝硬化患者中HVR1抗体的检出率分别为90.5%、95.1%和94.7%,并无显著差异(P>0.05);而这3组患者血清中HVR1抗体异质程度分别为5.39±3.75、11.74±3.29和10.61±4.09;慢性肝病变和肝硬化患者组的抗体异质程度要显著高于急性患者组(P<0.01)。结论:HCV慢性感染的严重程度与HVR1抗体的异质程度相关,但与HVR1抗体的存在情况无关。Objective： To analyze antibody response to hypervariable region 1 （HVR1） in chronic hepatitis C virus infection. Methods： Fused HVR1 antigens were used to detect the appearance of HVR1 antibodies by ELISA. Multi-target HVRls antigen was used to detect the heterogeneity of HVR1 antibodies. Results：The positive rate of HVR1 antibodies was 90.5% in asymptomatic patients,95.1% in chronic hepatopathy patients, and 94.7% in cirrhosis patients. There was no difference between the three groups. The HVR1 antibody＇s heterogeneity in the three groups was 5.39 ± 3.75, 11.74 ± 3.29 and 10.61 ±4.09 respectively. The heterogeneity in chronic hepatopathy and cirrhosis patients was much higher than that in the asymptomatic ones （P 〈 0.01 ）. Conclusion：The progress of chronic hepatitis C virus infection is related to het- erogeneity of HVR1 antibodies, rather than the appearance of HVR1 antibodies.

关 键 词：丙型肝炎病毒 第一高变区 异质性 

分 类 号：R512.63[医药卫生—内科学]