坎地沙坦治疗心力衰竭效果及对脑钠素水平的影响  

EFFECTS OF CANDESARTAN ON PLASMA BRAIN NATRIURETIC PEPTIDE IN PATIENTS WITH CONGESTIVE HEART FAILURE

作　　者：闫立群[1] 罗戈南 庞继恩[3] 

机构地区：[1]青岛大学医学院,山东青岛266021 [2]青岛市公安消防医院 [3]中国人民解放军第401医院心内科

出　　处：《齐鲁医学杂志》2008年第4期329-330,334,共3页Medical Journal of Qilu

摘　　要：目的研究血管紧张肽Ⅱ(AngⅡ)受体拮抗剂坎地沙坦对充血性心力衰竭(CHF)的治疗作用及其对脑钠素(BNP)水平影响。方法60例CHF病人随机分为两组,对照组(n=30)用强心剂和利尿剂治疗,坎地沙坦治疗组(n=30)在前者治疗基础上加用坎地沙坦酯片(8 mg/d)治疗,疗程12周。观察治疗前后两组病人NYHA分级、心脏超声指标、血浆BNP浓度的变化。结果经12周治疗后,坎地沙坦治疗组血浆BNP水平明显降低(t=4.89,P<0.01),左室射血分数有所提高(t=4.26,P<0.01),病人心功能较前改善。结论在常规治疗的基础上加用坎地沙坦治疗CHF能明显降低血浆BNP的水平,更好地改善CHF病人的心功能。降低血浆BNP水平可能是AngⅡ受体拮抗剂治疗CHF的机制之一。Objective To investigate the effect of Candesartan on patients with congestive heart failure （CHF） and on the plasma brain natriuretic peptide （BNP） level. Methods Sixty patients were evenly divided into control group （cardiac tonic and diuretic） and treatment group （medicine used in control group plus Candesartan 8 mg/d for 12 weeks）. The changes of NYHA class and BNP level were detected. Results After the therapy, BNP levels in treatment group were significantly lower than those of the control group （t=4.89,P〈0.01）. EF partly improved （t=4.26,P〈0.01）. Conclusion Candesartan may markedly de cline BNP level on the basis of routine therapy for patients with CHF and improve patient＇s heart function.

关 键 词：坎地沙坦 心力衰竭 充血性 利钠肽 脑 治疗结果 

分 类 号：R541.6[医药卫生—心血管疾病]