新生儿高胆红素血症与听觉脑干诱发电位的观察  

Observation of neonatal hyperbilirubinemia and brainstem auditory evoked potentials

作　　者：周晓丽[1] 何金根[1] 陆达林[1] 

机构地区：[1]安徽医科大学附属省立医院儿科,安徽合肥230001

出　　处：《安徽医药》2008年第10期929-931,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨高胆红素血症患儿听觉脑干诱发电位异常的危险因素及在高胆红素血症处理中的价值。方法对147例足月新生儿高胆红素血症患儿检测血清总胆红素(TBC)、总胆红素/白蛋白(B/A)比值、二氧化碳结合力、血糖,并根据听觉脑干诱发电位检测的结果,分组对病因、黄疸出现时间、就诊时日龄、体重的变化及TBC、B/A、二氧化碳结合力、血糖进行对比观察。结果147例患儿BAEP正常81例,异常66例。BAEP正常组和异常组的TBC、B/A比值、二氧化碳结合力比较,差异有显著性(P<0.05);两组血糖水平及体重丢失百分比,差异无统计学意义(P>0.05)。病因中新生儿溶血病两组比较具有统计学意义(P<0.05);两组黄疸出现时间在24 h内差异有显著性(P<0.05);7 d内就诊两组差异无显著性(P>0.05)。结论黄疸出现早、新生儿溶血病、胆红素水平高、B/A比值高、低二氧化碳结合力是听觉脑干诱发电位异常的危险因素。Aim To explore the risk factors of abnormal brainstem auditory evoked potentials of hyperbilirubinemia newborn and its value in the treatment of the neonatal hyperbilirubinemia. Methods The examinations of the serum total bilirubin,the ratio between the total bilirubin and the albumin, the carbon dioxide combining power（ CO2 CP）, and the blood glucose concentration of the 147 full-term newborn with hyperbilirubinemia were made, and contrast observations on the etiology,the emerging time of jaundice, the visited day-old,the weight change, the serum total bilirubin, the ratio between the total bilirubin and the albumin, the CO2 CP, and the blood glucose concentration were carried out by groups according to the results of brainstem auditory evoked potentials. Results In the 147 cases,81 cases were normal and 66 cases were abnormal. The difference between the two groups was significant in the following indexes ： the serum total bilirubin, the ratio between the total bilirubin and the albumin, the CO2 CP（ P 〈 0.05 ） ; however, there was no significant difference in the following two indexes ： the blood glucose and the percentage of body weight loss （ P 〉 0.05 ） and the difference was statistically significant when comparing different etiology of hemolytic disease of newborn. In two groups, there is significant difference in the emerging time of jaundice in 24 hours but no difference in 7 days before the visited day. Conclusion Early appearance of jaundice, hemolytic disease of newborn, the high level of bilirubin, the high ratio between the total bilirubin and the albumin, the low carbon dioxide combining power （CO2CP） are the risk factors of abnormal BAEP.

关 键 词：新生儿 高胆红素血症 听觉脑干诱发电位 

分 类 号：R722.1[医药卫生—儿科]