含瓜尔树胶的半互穿网络凝胶的制备及性能  

Preparation and Properties of Semi-interpenetrating Polymer Network Hydrogels Containing Guar Gum

作　　者：李胜方[1] 刘先利[1] 左小华[1] 吴桂英[1] 

机构地区：[1]黄石理工学院化学与材料工程学院,湖北黄石435003

出　　处：《黄石理工学院学报》2008年第4期31-34,共4页Journal of Huangshi Institute of Technology

摘　　要：以水为介质,在室温下合成了聚甲基丙烯酸-瓜尔树胶半互穿网络凝胶。凝胶表现出良好的pH敏感性,在酸性条件下凝胶网络上羧基间致密的氢键复合结构使其表现出最小程度的溶胀,而在pH 7.4时羧基离子化导致的静电排斥作用使其表现出最大程度的溶胀。凝胶体外降解表明其降解率(R%)依赖于凝胶的交联密度和瓜尔树胶含量.The semi -IPN hydro gel Composed of poly （methacrylic acid） and guar gum were prepared at room temperature using water as solvent. The hydro gel showed excellent pH - sensitivity. It exhibited minimum swelling in an acidic pH medium through the formation of a complex hydrogen - bonded structure and maximal swelling due to the electrostatic repulsion due to the ionization of the carboxylic groups in pH 7.4 medium. The degradation in vitro showed that the degree of degradation （ R% ） depended on the crosslinking density and content of guar gum.

关 键 词：瓜尔树胶 半互穿网络凝胶 体外酶降解 

分 类 号：R943[医药卫生—药剂学]