强噪声引起的大鼠应激反应  

The Stress Reaction Induced by Intensive Noise Exposure in Rats.

作　　者：郑素贤[1,2] 钱维权 王宝珍[1,2] 史秀凤[1,2] 梁振福[1,2] 胡正元[1,2] 

机构地区：[1]航天医学工程研究所 [2]海军医学研究所

出　　处：《航天医学与医学工程》1997年第5期333-336,共4页Space Medicine & Medical Engineering

摘　　要：为研究长时间的强噪声对大鼠的影响，５０只雄性ＳＤ大鼠随机分为５组：正常对照组、噪声暴露（１２０ｄＢＳＰＬ宽带噪声，每天２ｈ）１ｄ、３ｄ、７ｄ和１４ｄ组。结果表明：噪声暴露后，血清ＡＣＴＨ和皮质酮含量增加，间脑ＤＡ含量减少，肾上腺重量增加，胸腺及脾脏重量减轻，表明机体发生了应激反应。同时观察到，暴露７ｄ，肾上腺及胸腺重量变化最大，暴露１４ｄ，血清ＡＣＴＨ含量下降，间脑ＤＡ含量降至最低，肾上腺及胸腺重量基本恢复正常。提示，从暴露７ｄ起，应激的急性反应开始减弱，暴露１４ｄ时开始转入慢性抑制状态。To study the effects of sustained intensive noise on rats,fifty SD male rats were randomly divided into:control group and 1 d,3 d,7 d and 14 d noise exposure groups(120 dBSPL,broadband noise,2 h daily).The results showed that after noise exposure,the ACTH level and the corticosterone level in serum increased,but the content of DA in diencephalon decreased,the weight of adrenal gland increased, while that of thymus and spleen decreased.Change of weight of adrenal gland and thymus became maximum after 7d-exposure.The ACTH level in serum and the content of DA in diencephalon decreased and the later reached the lowest value and the weight of adrenal gland and thymus returned to normal level after 14 d exposure. It indicated that the acute response began to decrease after 7d-exposure,and the response turned into a chronic inhibitoty state after 14d-exposure.

关 键 词：噪声 应激反应 促肾上皮质激素 多巴胺 大鼠 

分 类 号：R852.24[医药卫生—航空、航天与航海医学]