前列腺增生症与前列腺癌微血管密度计数的比较  

The Experimental Comparison of Microvessel Density in Normal Prostate、Benign Prostatic Hyperplasia and Prostate Cancer

作　　者：丁滔[1] 李解方[1] 丁平[1] 曹友汉[1] 刘志文[1] 段友军[1] 

机构地区：[1]南华大学第一附属医院泌尿外科,湖南衡阳421001

出　　处：《南华大学学报（医学版）》2008年第3期323-325,共3页Journal of Nanhua University(Medical Edition)

摘　　要：目的测定正常前列腺(NP)、前列腺增生症(BPH)、前列腺癌(PC)三者中及前列腺癌不同病理分级、临床分期中微血管密度计数,比较微血管密度计数在它们中的差别。方法应用链霉菌素抗生物蛋白-过氧化酶方法,用CD34单克隆抗体对正常前列腺、前列腺增生症、前列腺癌行免疫组织化学染色,采用Weinder方法对CD34标记的微血管密度进行定量计数。结果微血管密度在正常前列腺、前列腺增生症、前列腺癌三组中计数分别为15.10±2.33、27.63±3.67、60.20±15.53;微血管密度在PC高、中、低分化细胞病理学分级三组中的计数分别为44.30±3.90、56.10±4.61、81.47±5.90;微血管密度在前列腺癌临床分期A、B、C、D期四组中的计数分别为48.67±7.2、54.79±10.81、72.00±16.31、65.73±15.44,各组差异均具有显著性(P<0.01)。结论微血管密度计数在前列腺癌高于前列腺增生症、前列腺增生症高于正常前列腺,微血管密度计数在前列腺癌随着细胞病理学分级的降低和临床分期的升高而增加。Objective To evaluate microvessel density （MVD） count in normal prostate （NP）, benign prostatic hyperplasis （BPH）, and prostate cancer（PC） ,as well as in different grading both pathological and clinical system. The aim of our work is to explore significance of MVD in the development of BPH and PC as well as their possible application to clinical diagnosis. Methods According to pathological grade, PC were divided into three groups： 16 high-grade, 19 moderate-grade, 15 low-grade. According to clinical stage, PC were divided into four groups： 12 A, 14 B, 13 C, liD. quantitative method of Weidner with monoclonal antibody CD34 was employed for MVD count. Results The mean MVD count was shown as followed： NP 15.10±2.33, BPH 27.63±3.67, PC 60.20±15.53. According to pathological grade, the mean MVD count was shown as followed： high-grade 44.30±3.90, moderate-grade 56.10±4.61, low-grade 81.47±5.90. According to clinical stage, the mean MVD count was shown as followed： A 48.67±7.20, B 54.79±10.81, C 72.00±16.31, D 65.73±15, 44. The differences were statistically significant in groups both of various pathological grades and clinical stages （P〈0.01）. Condusions Our study indicated that prostatic hyperplasia and malignant changes were closely associated with scores of MVD count. It appears that indexe could be used as the basis to delineate a diagnostic criterion for differentiation of BPH and PC.

关 键 词：微血管密度 前列腺增生症 前列腺癌 

分 类 号：R697.3[医药卫生—泌尿科学]