肾康丸对糖尿病大鼠肾脏病理的影响  

Effect of Shenkangwan on the Renal Pathology in Diabetic Rats

作　　者：肖炜[1] 蔡红兵[1] 李欣[2] 

机构地区：[1]南方医科大学中医药学院,广州510515 [2]南方医科大学蛋白质组学重点实验室,广州510515

出　　处：《光明中医》2008年第9期1258-1260,共3页GUANGMING JOURNAL OF CHINESE MEDICINE

基　　金：广东省自然基金资助项目(No:7300233)

摘　　要：目的:观察肾康丸对糖尿病(DM)模型大鼠肾脏病理的影响。方法:用链脲佐菌素(STZ)腹腔注射法诱导建立大鼠DM模型,模型成功后随机分为3组,治疗8w。末次治疗后,观察肾脏大小,计算肾重、相对肾重,并通过HE、Masson染色法和电镜观察大鼠肾脏组织病理变化。结果:在治疗期间的8周里,模型组大鼠血糖均维持在16.7mmol·L-1以上;8w后,大鼠肾脏重量及相对肾重增加(P<0.01),且出现了相当于Mogensen分期的3期左右DN病理损害。肾康丸可以改善大鼠基本状况,降低上述指标水平(P<0.01或P<0.05),减轻肾脏组织病理损害。结论:肾康丸具有保护DM大鼠肾脏的作用。Objective： To investigate the effect of Shenkangwan on renal pathology in diabetic rats. Methods：The diabetic rat models were induced by intraperitoneal injection of streptozotocin （STZ） and randomly divided into 3 groups：model control group; Capoten group and Shenkangwan group. Some other rats were used as normal control group. All rats were treated with corresponding drugs for 8 weeks. During and after the treatment, the general state, blood glucose levels of the rats in every group were observed. After treated in the last time, we took out the kidneys of the rats, observed the size and volume of them and measured the kidney weight and relative kidney weight. Then we investigated their renal pathological changes by optical microscope with the coloration method of Hematoxylin and Eosin （HE） and Masson and electron microscope. Results： During the treating eight weeks, The model rats blood glucose were all over 16.7 mmol· L^-1 . And they appeared the symptom of the DM such as the quantum of drinking, eating and urinating increased. Their kidney weight and relative kidney weight increased distinctly （ P 〈 0.01 ） and came forth about the 3 stages renal pathological lesions according to the stages of Mogensen.Shenkangwan could ameliorate the rat＇ general state, decrease the above indexes markedly （ P 〈 0.01 or P 〈 0.05） and mitigate the renal pathological lesion. Conelusion：Shenkangwan has a certain protective effect on the kidney of diabetic rats.

关 键 词：肾康丸 糖尿病肾病 病理 

分 类 号：R285.5[医药卫生—中药学]