C肽在糖尿病慢性并发症发生和发展中的作用及其机制  

Effects of C-peptide on development of chronic diabetic complications and its mechanism

作　　者：王建[1] 陈红[1] 

机构地区：[1]上海交通大学医学院药理教研室,200025

出　　处：《中华内分泌代谢杂志》2008年第4期463-464,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金重点项目（30330650）

摘　　要：近年来的研究显示，C肽能够特异性地结合到细胞表面，通过多种机制在糖尿病慢性并发症的发生发展中起着重要作用，如C肽可以减轻肾脏的高滤过状态，减少高渗性利尿和白蛋白渗出，改善糖尿病患者的微循环，增加患者的心功能，预防和逆转神经病变。本文综述了C肽在糖尿病并发症发生和发展中的作用及其机制。Recent studies have suggested that C-peptide in the nanomolar concentration range binds specifically to cell surfaces and plays an important role in the pathological mechanism of chronic complications of diabetes mellitus, via improving the microcirculation, diminishing glomerular hyperfiltration, reducing urinary albumin excretion, protecting the cardiac function and preventing nerve dysfunction. The effects of C-peptide on the development of the chromic diabetic complications and its mechanisms are reviewed.

关 键 词：C肽 C肽受体 糖尿病慢性并发症 

分 类 号：R587.2[医药卫生—内分泌] R587.1[医药卫生—内科学]