大鼠多通道人工耳蜗植入模型的建立  

A rat model for cochlear implant research

作　　者：卢伟[1] 徐瑾 Shepherd R K 

机构地区：[1]郑州大学附属第一医院耳鼻咽喉科,郑州450052 [2]The Bionic Ear Institute,Australia [3]Department of Otolaryngology,University of Melbourne,Australia

出　　处：《临床耳鼻咽喉头颈外科杂志》2008年第13期603-605,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家留学基金(No:22841039);United States National Institutes of Health(No:NIH-NO1-DC-3-1005)联合资助

摘　　要：目的:建立多通道人工耳蜗植入的大鼠动物模型。方法:5只正常听力的Hooded Wister大鼠经药物致聋后,采用在前期研究中所创立的新手术步骤,在鼓阶内植入多通道电极。对双极电刺激诱发的听性脑干反应(EABRs)进行分析,对耳蜗组织学切片进行评价。结果:在电极植入后,顺利描记到正常EABRs波形,从而确认了有效的人工耳蜗功能状态。组织学观察表明,电极植入后的大鼠耳蜗内未见组织结构的严重损伤。结论:本文介绍的大鼠多通道人工耳蜗植入法有效、安全,所建立的大鼠动物模型为进行多通道人工耳蜗植入研究提供了一个新的途径;也为其他小啮齿动物(如沙鼠和小鼠)的实验性耳显微外科研究提供了思路。Objective：To introduce a rat model for use in cochlear implant related research. Method：Five deafened Hooded-Wistar rats were implanted with a scala tympani electrode array using a new surgical method. Electrically evoked brainstem responses （EABRs） using bipolar stimulation were recorded and cochlear histogy was assessed. Result：Electrically evoked brainstem responses with normal configuration confirmed the functional status of the cochlear implantation. There was no evidence of severe insertion-induced damage of intra-cochlear structure. Conclusion：The surgical method established in the rat model is a safe and effective procedure for acute or chronic cochlear implantation.

关 键 词：人工耳蜗植入 大鼠 耳蜗 听性脑干反应 

分 类 号：R318.18[医药卫生—生物医学工程]