P-body及其与mRNA的转录后调节之间的关系  

P-body and Its Involvement in Post-transcriptional Gene Regulation

作　　者：张义玲[1] 郭艳合[1] 王毅刚[1] 刘立[1] 钱程[1] 

机构地区：[1]浙江理工大学生命科学学院 新元医学与生物技术研究所,杭州310018

出　　处：《中国生物化学与分子生物学报》2008年第8期685-691,共7页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家重点基础研究发展规划(973计划,No.2004CB518804);国家高科技研究发展计划(863计划,No.2006AA02Z126;2007AA02Z134);浙江省科技支撑与攻关计划面上项目(No.2007C33027)资助~~

摘　　要：mRNA在真核生物基因表达的转录后调控中发挥着重要作用.然而最新研究发现,一种被命名为P-body胞浆复合体是mRNA转录后调控过程中的一个重要场所,在基因表达过程中起到了至关重要的调控作用.该复合体富含多种功能的蛋白,同时还有细胞因子与RNA等成分组成,其功能特征为参与mRNA降解、翻译抑制、mRNA监视以及RNA介导基因沉默等重要生命活动过程.研究发现,P-body是特化的细胞成分.本文详细阐述P-body的发现、结构特征以及与mRNA转录后调控的关系,使人们对P-body的生物学功能有更深入地了解和认识,另一方面将有助于更进一步深入探讨基因的表达调节机制.Post-transcriptional regulation of mRNA plays expression. Recently, many studies demonstrated that a significant role in the progress of eukaryotic gene P-body, a multifunctional cytoplastic complex of proteins and RNAs, was important for mRNA post-transcriptional regulations. Various cytokines in P-body are involved in mRNA degradation, translation inhibition, mRNA surveillance and mRNA-mediated gene silencing, etc. Researches have also indicated that P-body was a specialized cellular component that would provide more profound insights for its biology significance in the regulation of gene expression. In this review, we summarized the current knowledge of P-body for its discovery, structure characterization and relationship with post-transcriptional regulation of mRNAs.

关 键 词：P-BODY MRNA降解 mRNA监视 转录后调节 

分 类 号：Q78[生物学—分子生物学]