汉族男性血管紧张素转化酶基因Ⅰ/D多态性与耐力训练敏感性的关联研究  

RESEARCH ON THE RELATION BETWEEN ACE GENE Ⅰ/D POLYMORPHISMS AND SENSITIVITY TO ENDURANCE TRAINING OF HAN NATIONALITY MALE

作　　者：席翼[1] 武雅琼[2] 张秀丽[3] 胡扬[4] 刘刚[4] 张海霞[4] 包大鹏[4] 吴剑[4] 

机构地区：[1]天津体育学院运动人体科学系,天津300381 [2]深圳大学师范学院体育系,深圳518060 [3]南开大学体育学部,天津300000 [4]北京体育大学运动人体科学院,北京100084

出　　处：《中国应用生理学杂志》2008年第3期262-267,共6页Chinese Journal of Applied Physiology

基　　金：国家科技部资助课题(2003BA904B04)

摘　　要：目的:探讨耐力训练对有氧能力的影响与血管紧张素转化酶(ACE)基因Ⅰ/D(插入/缺失)多态性的关联性,以探寻影响耐力训练敏感性的基因标记。方法:选择102名北方汉族新兵,进行18周的5km跑训练,测定训练前后最大摄氧量(.VO2max)、通气无氧阈(VT)和定量负荷时动态左心室结构与功能指标,并应用PCR-AFLP方法检测其ACE基因Ⅰ/D多态。结果:耐力训练后、.VO2max、VT和左心室结构与功能均发生了良好的顺应性改变;ⅠD型和Ⅱ型的△V.O2max显著高于DD型(P<0.05),△V.O2max的组间差异有显著性(P<0.05),Ⅱ型的△V.O2VT显著高于DD型(P<0.05)。结论:Ⅰ等位基因在.VO2max和VT的训练敏感性方面具有明显的遗传优势,Ⅱ基因型与VT训练敏感性有一定关联,未发现I/D多态性与左心室动态功能指标的训练敏感度之间有关联关系。Aim： In order to seek the marks of the genes, the relation between the influence of endurance training on aerobic ability and ACE Gene I/D Polymorphisms were studied. Methods： I02 army recruits of Han nationality from North China for an 18-week endurance training of 5000m distance. Their VO2max, VT and the left ventricular structure and function were measured before and after the training. We also tested their ACE Gene I/D Polymorphisms with PCR-AFLP method. Results： The compliance of VO2max, VT and left ventricular structure and function had improved after the training; the △VO2max of ID and Ⅱ type was obviously higher than that of DD type （ P 〈 0.05） ; there was obviously diference of △VO2VT in different ACE genotype （ P 〈 0.05 ）, the △VO2VT of type Ⅱ was obviously higher than that of DD type （ P 〈 0.05）. Conclusion： I allele has obviously hereditary advantage on the sensitivity to aerobic training in △VO2max and VT, and type Ⅱ has relation on the sensitivity to aerobic training in VT; there is no relation between I/D polymorphism and the sensitivity to aerobic training on the structure and function of left ventricle.

关 键 词：汉族 ACE基因I/D多态 最大摄氧量 通气无氧闽 左心室结构与功能 耐力训练 

分 类 号：G804.23[文化科学—运动人体科学] Q786[文化科学—体育学]