Non-invasive measurement and validation of tissue oxygen saturation covered with overlying tissues  

作　　者：Yichao Teng Haishu Ding Lan Huang Yue Li Quanzhong Shan Datian Ye Haiyan Ding Jenchung Chien Betau Hwang 

机构地区：[1]Department of Biomedical Engineering, School of Medicine, Room C217, Building of Medical Science, Tsinghua University, Beijing 100084, China [2]Hefei Anheng Optic-electronic Co. Ltd., Hefei 230031, China [3]Department of Clinical Laboratories, First Hospital of Tsinghua University, Beijing 100016, China [4]Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China [5]Department of Pediatrics, Taipei Veterans General Hospital, Taipei, China

出　　处：《Progress in Natural Science:Materials International》2008年第9期1083-1088,共6页自然科学进展·国际材料（英文版）

基　　金：National Natural ScienceFoundation of China (Grant Nos. 39670799, 69778024,and 60578004);China Postdoctoral Science Founda-tion (Grant No. 20070410514)

摘　　要：In this paper, the biological tissue oxygen saturation （rSO2） is obtained non-invasively and in real time based on near infrared spectroscopy （NIRS） using two emitting wavelengths and two detectors, where the tissue is covered with overlying tissues. Our group developed an NIRS oximeter based on the above principle independently, and validated it using liquid tissue model calibrations and animal experiments. The results indicate that （1） in the normal range of tissue oxygen saturation （40-70%）, the rSO2 measured by NIRS is accurate enough and little influenced by the background absorptions （such as the absorption of water） and overlying tissues （such as fat）; （2） during cerebral hypoxia and recovery of three piglets, there is excellent correlation （p 〈 0.001） between cerebral rSO2 and jugular venous oxygen saturation （SjO2）, meaning that the rSO2 can be indicated by the SjO2 to a large extent; during the death of the three piglets induced by heart beat stopping, cerebral rSO2 decreases continuously to significantly low levels （〈25%） because cerebral blood supply does not exist any more. All the above results are of explicit physiological importance.In this paper, the biological tissue oxygen saturation (rSO2) is obtained non-invasively and in real time based on near infrared spec-troscopy (NIRS) using two emitting wavelengths and two detectors, where the tissue is covered with overlying tissues.Our group devel-oped an NIRS oximeter based on the above principle independently, and validated it using liquid tissue model calibrations and animal experiments.The results indicate that (1) in the normal range of tissue oxygen saturation (40-70%), the rSO2 measured by NIRS is accu-rate enough and little infiuenced by the background absorptions (such as the absorption of water) and overlying tissues (such as fat);(2) during cerebral hypoxia and recovery of three piglets, there is excellent correlation (p < 0.001) between cerebral rSO2 and jugular venous oxygen saturation (SjO2), meaning that the rSO2 can be indicated by the SjO2 to a large extent;during the death of the three piglets induced by heart beat stopping, cerebral rSO2 decreases continuously to significantly low levels (<25%) because cerebral blood supply does not exist any more.All the above results are of explicit physiological importance.

关 键 词：Tissue oxygen saturation Jugular venous oxygen saturation Overlying tissues Non-invasive measurement 

分 类 号：O611.62[理学—无机化学]