不同配电离子的Gd^Ⅲ-三乙四胺六乙酸配合物与牛血清蛋白相互作用的圆二色光谱研究  

Circular dichrois study on the interaction between Gd^Ⅲ-TTHA complexes and BSA of different positive ions

作　　者：任百祥[1] 

机构地区：[1]吉林师范大学环境工程学院,吉林四平136000

出　　处：《辽宁师范大学学报（自然科学版）》2008年第3期326-328,共3页Journal of Liaoning Normal University:Natural Science Edition

摘　　要：GdⅢ-氨基多羧酸配合物(如Gd-dtpa、Gd-edta、Gd-ttha)常被作为磁共振成像(MRI)造影剂,其作用机制是通过体内局部组织中水分子氢核的弛豫速率而提高正常与病灶部位对比度或显示器官的功能状态和血液流动情况.本文报道了采用圆二色光谱法研究GdⅢ-三乙四胺六乙酸配合物与血清蛋白之间的相互作用及其影响因素,并发现二者之间存在着微弱的静电作用,而且这种作用随着配合物结构的不同而不同,这对选择适当的造影剂,降低Gd进入体内的数量具有一定的指导意义.Gd^Ⅲ-aminopolycarboxglicacid complexes （Gd-dtpa.Gd-edta.Gd-ttha） are usually used as contrast agent of MRI, whose function is to raise the contrast ratio between normal and sick position, the functional state of the human organs and the flowing condition of blood by changing the relaxation rate of the water 1H in partical tissue of human body. In this paper, we study the interaction between Gd^Ⅲ-TTHA complexes of different positive ions and BSA by CD. The results indicate that there is electrostatic action between them and some relevcent factors and this kind of action is different for different structures. This has some guiding significans for choice of contrast agent and reducing Gd to enter the body.

关 键 词：Gd^Ⅲ-三乙四胺六乙酸配合物 牛血清蛋白 相互作用 圆二色光谱 

分 类 号：O641.4[理学—物理化学]