医学吸虫抗氧化酶家族的研究进展  

Research Progress on the Antioxidant Enzyme Family in Medical Trematode

作　　者：蔡国斌[1] 董惠芬[1] 蒋明森[1] 

机构地区：[1]武汉大学基础医学院人体寄生虫学教研室,武汉430071

出　　处：《中国寄生虫学与寄生虫病杂志》2008年第4期313-317,共5页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：需氧生物体在正常生理代谢过程中会产生活性氧族(reactive oxygen species,ROS),但过多的ROS可引起体内多种氧化损伤,因此这类生物体都具备一套完善的防御体系,抗氧化酶是其中一个重要的组成部分。对于医学吸虫,不仅需要抗氧化酶清除正常生理代谢中产生的ROS,还要抵抗宿主免疫系统来源的ROS引起的损伤。了解医学吸虫抗氧化酶家族的结构和特性,有助于对其生殖生理的研究,以及新型药物和疫苗的开发。本文综述近年来对医学吸虫谷胱甘肽过氧化物酶(glutathione peroxidase,GPx)、超氧化物歧化酶(superoxide dismutase,SOD)及抗氧化蛋白(peroxire-doxin,PRx)等抗氧化酶家族的研究进展。Reactive oxygen species （ROS）, generated in the metabolism process of aerobic organisms, can induce oxidative damages in the body. These organisms are all equipped with an excellent defense system to protect themselves and antioxidant enzymes play an important role in the system. Parasitic trematodes have to eliminate ROS not only from themselves but also from the immune system of their hosts. To better understand the structures and specialities of the antioxidant enzymes in trematodes is conducive to the study on reproductive physiology of trematode and on drug and vaccine development. This paper summarizes the research progress on the family of antioxidant enzymes in trematodes including glutathione peroxidase （GPx）, superoxide dismutase （SOD） and peroxiredoxin （PRx） in the past decades.

关 键 词：抗氧化酶 医学吸虫 活性氧族 

分 类 号：R383.2[医药卫生—医学寄生虫学]