半胱氨酰白三烯受体与脑损伤关系的研究进展  

Research advance in cysteinyl leukotriene receptors with brain injury

作　　者：张丽慧[1] 赵建波[1] 王艳芳[1] 张纬萍[2] 魏尔清[2] 

机构地区：[1]杭州师范大学基础医学院药理教研室,浙江杭州310036 [2]浙江大学医学院药理学系,浙江杭州310058

出　　处：《浙江大学学报（医学版）》2008年第3期315-320,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金资助项目(30672449,30772561);浙江省自然科学基金资助项目(Y204210)

摘　　要：近年来发现,半胱氨酰白三烯CysLT1和CysLT2受体参与整体水平脑缺血和脑外伤后神经损伤。CysLT1受体调节脑缺血后血脑屏障通透性增高、血管性脑水肿,介导星形胶质细胞增殖及炎症反应;CysLT2受体调节脑缺血后AQP4表达增加、细胞性脑水肿,介导星形胶质细胞损伤;新发现的GPR 17也与脑缺血损伤有密切关系。加深CysLT受体在脑损伤及神经保护中作用的认识,将为CysLT受体作为药物靶点筛选和开发防治脑损伤的药物提供新的途径。Based on the findings recently reported,cysteinyl leukotriene receptors,both CysLT1 and CysLT2 receptors, are involved in the isehemie and traumatic brain injury in vivo. CysLT1 receptor regulates the increased permeability of blood-brain barrier and the related vasogenie brain edema, astroeyte proliferation, and inflammatory responses after brain isehemia; while CysLTz receptor regulates AQP4 expression and the related eytotoxie brain edema,and astroeyte injury. A new subtype of CysLT reeeptor,GPR17,is also involved in brain isehemie injury. The roles of CysLT receptors in brain injury or neuroproteetion from the injury should be further understood. This understanding is necessary to accelerate the screening and development of the new drugs for the prevention and treatment of brain injury with the receptors as therapeutic targets.

关 键 词：半胱氨酰白三烯受体 脑疾病 脑损伤 

分 类 号：R651.15[医药卫生—外科学]