胃黏膜相关淋巴样组织淋巴瘤中p16蛋白和Ki-67抗原的表达及意义  

The significance of p16 protein and Ki-67 antigen expression in gastric mucosa-associated lymphoid tissue lymphoma

作　　者：杨跃[1] 魏振军[1] 翟云[1] 刘斌[1] 梁浩[1] 

机构地区：[1]解放军总医院消化内科,北京100853

出　　处：《中华内科杂志》2008年第9期743-745,共3页Chinese Journal of Internal Medicine

摘　　要：目的探讨p16蛋白和Ki-67抗原在胃黏膜相关淋巴样组织淋巴瘤（MALTL）发生、发展中的作用。方法选择我院病理科1993年3月至2005年6月期间经病理诊断的胃MALTL手术标本，均经2位以上病理科医师会诊筛选，从中确定胃MALTL患者47例。应用免疫组织化学法检测p16蛋白和Ki-67抗原在20例正常胃黏膜组织和47例胃MALTL组织中的表达。结果胃MALTL组织中p16蛋白表达阳性率21．3％（10／47）明显低于胃正常组织（90．0％）。伴淋巴结转移的胃MALTL组织中p16蛋白阳性率低于无淋巴结转移组（P〈0．05），Ki-67抗原表达的阳性率为87．2％（41／47），明显高于胃止常组织（P〈0．05）。p16蛋白表达与Ki-67分级呈明显负相关（P〈0．05）。结论联合检测p16蛋白和Ki-67抗原有助于评估胃MALTL患者的预后及指导临床治疗。Objective To detect the expression of p16 protein and Ki-67 antigen in gastric mucosaassociated lymphoid tissue lymphoma （MALTL） and normal gastric mucosa and to investigate the clinical significance of their expression in the occurrence and development of gastric MALTL. Methods 47 samples of gastric MALTL diagnosed pathologically in the department of pathology of the PLA General Hospital from March 1993 to June 2005 were collected. By using immunohistochemial methods, the expression of p16 protein and Ki-67 antigen was detected in 20 samples of normal gastric tissue and the 47 samples of gastric MALTL. Results The positive rate of p16 protein was 21.3% （10/47） and 90. 0% in gastric MALTL and normal gastric tissue respectively. The positive rate of p16 protein in gastric MALTL was lower than that in nonnal gastric tissue（ P 〈 0. 05 ）. The expression of p16 was related to the degree of lymph node metastasis. The positive rate of Ki-67 labelling index （LI） iu gastric MALTL was higher than that in normal gastric tissue. A negative correlation was found between the expression of p16 protein and Ki-67 LI（P 〈 0. 05 ）. Conclusions Detection p16 and Ki-67 may help to predict the possibility of lymph node metastasis and prognosis in gastric MALLTL.

关 键 词：胃 淋巴瘤 黏膜相关淋巴样组织 蛋白质P16 KI-67抗原 

分 类 号：R686[医药卫生—骨科学]