单用伊曲康唑及联合γ-干扰素对小鼠白假丝酵母菌感染抗菌作用的实验研究  

The single itraconazole and combination with interferon-γ against candida albicans infection

作　　者：廖晓容[1] 高永良[1] 周汛[1] 

机构地区：[1]重庆医科大学附属第一医院皮肤科,重庆400016

出　　处：《重庆医科大学学报》2008年第9期1092-1095,共4页Journal of Chongqing Medical University

摘　　要：目的:研究单用伊曲康唑(Itraconazole)及联合γ-干扰素(IFN-γ)对小鼠白假丝酵母菌感染的抗菌作用。方法:制备系统性白假丝酵母菌感染小鼠模型,单用不同剂量伊曲康唑及联合γ-干扰素治疗感染小鼠。取肝、肾组织培养及组织切片,通过计数菌落形成单位(CFU)及组织病理切片情况,判定单用伊曲康唑及联合γ-干扰素抗白假丝酵母菌感染的作用。结果:伊曲康唑10mg/kg与105Uγ-干扰素联合应用白假丝酵母菌感染有较好的协同作用,而伊曲康唑50mg/kg与105Uγ-干扰素联合应用其协同疗效不显著。50mg/kg伊曲康唑组单用有很好的抗白假丝酵母菌作用。结论:小剂量的伊曲康唑与γ-干扰素联合应用对小鼠系统性白假丝酵母菌感染有较好的协同作用。大剂量伊曲康唑单用也有很好的抗菌原理。Objective：To study the efficacy of single itraconazole and combination with interferon-γ against Candida albicans infection. Methods：Murine models of systemic candida albicans infection were established, and treated with different concentrations of itraconazol alone and combination with INF-γ. Then the concentrations of colonyforming units（cfu） and histolo gical sections were observed to evaluate the emcacy. Results：The combination of 10^5U INF-γ and itraconazole at the dosage of lOmg/kg showed better effect against Candida albicans than the combination of itraconazole at the dosage of 50mg/kg with 10^5U INF-γ. Conclusion：The combination of itraconazole at a low dose with INF-γ shows a good effect against Candida albicans.The single use of itraconazole at a high dose is also anti-infection.

关 键 词：白假丝酵母菌 伊曲康唑 Γ-干扰素 菌落形成单位 

分 类 号：R751[医药卫生—皮肤病学与性病学]