注射用加替沙星与异烟肼注射液配伍的稳定性考察  

Study on the compatibility of gatifloxacin for injection and isoniazid injection

作　　者：杨继章[1] 赵增仁[1] 刘瑞琴[1] 杨树民[1] 杨丽丽[2] 

机构地区：[1]河北医科大学第一医院,河北石家庄050031 [2]河北医科大学药学院2003级毕业生

出　　处：《中国医院药学杂志》2008年第13期1053-1055,共3页Chinese Journal of Hospital Pharmacy

基　　金：河北省卫生厅科研课题[编号:冀卫科教字(2004)31-04177]

摘　　要：目的:考察注射用加替沙星与异烟肼注射液分别在0.9%氯化钠注射液和5%葡萄糖注射液中配伍的稳定性。方法:在室温(20±1)℃,观察两药配伍后的外观、pH值、含量及峰形变化,并用紫外双波长分光光度法测定加替沙星和异烟肼的含量。结果:两药配伍后,8h内的外观、pH值、含量及峰形均无明显变化。结论:在室温条件下,注射用加替沙星与异烟肼注射液在0.9%氯化钠注射液和5%葡萄糖注射液中配伍稳定。OBJECTIVE To study the compatibility of gatifloxacin for injection with isoniazid injection in 0. 9% sodium chloride injection and 5% glucose injection. METHODS A dual ultraviolet spectrophotometry was designed to study the change of content after compatibility of gatifloxacin and isoniazid at room temperature（20± 1 ）℃ for 8 hours, the change of the compatible liquid appearance and its pH and peak form were observed. RESULTS No significant change was found in 8 hours. CONCLUSION Gatifloxacin for injection can be mixed with isoniazid injection in 0. 9% sodium chloride injection and 5% glucose injection for use.

关 键 词：加替沙星 异烟肼 配伍 稳定性 

分 类 号：R969.2[医药卫生—药理学]