盐酸倍他洛尔药物树脂的制备及体外释药考察  

Preparation of betaxolol hydrochloride-resin complexes and the in vitro drug release

作　　者：吴春丽[1] 徐海伟[1] 单丽红[1] 刘宏民[1] 

机构地区：[1]郑州大学药学院,郑州大学新药研发中心,河南郑州450001

出　　处：《中国医院药学杂志》2008年第13期1077-1079,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:用静态法制备盐酸倍他洛尔的药物树脂并考察其释药动力学。方法:考察了不同温度和药物浓度对树脂交换速度的影响,并考察了药物树脂复合物在去离子水、0.5,1.0,2.0mol·L-1氯化钠和在0.5mol·L-1盐酸以及0.5mol·L-1氯化钾溶液中的释药动力学。结果:温度升高和药物浓度增大,药物与树脂的交换率增加。盐酸倍他洛尔药物树脂复合物体外释药速率随介质中离子强度的增加而增加。结论:该法制备倍他洛尔树脂复合物方法可行,凝胶型树脂可有效地控制倍他洛尔在体外的释放。OBJECTIVE To prepare betaxolol hydrochloride-resin complexes with bath method and study its in vitro drug release. METHODS The factors effecting exchange reaction kinetics of betaxolol hydrochloride were studied with different temperature and betaxolol＇s concentration. The drug release were investigated in different releasing media （deionic water, 0. 5 mol· L^-1 , 1.0 mol· L^-1 , 2. 0 mol· L^-1 NaCl, 0. 5 mol· L^-1 HCl and 0. 5 mol· L^-1 KCl）. RESULTS The exchange rates and drug-loading increased with increasing in temperatures and concentration. The release rate increased with increase of ionic strength of the medium. CONCLUSION Betaxolol hydroehloride-resin can be prepared and excellent release was suitable for new dosage forms.

关 键 词：盐酸倍他洛尔 药物树脂 静态法 体外释药动力学 

分 类 号：R943[医药卫生—药剂学]