加替沙星对住院患者血糖影响的随访研究  

A follow-up study of effects of gatifloxacin on blood glucose in inpatients

作　　者：周冰[1] 张俊[1] 裴振峨[1] 林鑫[2] 詹思延[2] 

机构地区：[1]北京市药品评价中心,北京100024 [2]北京大学公共卫生学院,北京100083

出　　处：《药物不良反应杂志》2008年第4期229-233,共5页Adverse Drug Reactions Journal

基　　金："国家药品不良反应重点监测管理方案研究"资助项目

摘　　要：目的:研究加替沙星对住院患者血糖的影响,为临床安全应用该药提供科学依据。方法:2007年5月至10月期间接受加替沙星或左氧氟沙星治疗的475例来自13所医院的住院患者纳入随访研究。其中加替沙星组230例,左氧氟沙星组245例。患者的给药剂量均为400 mg/d,静脉滴注,用药时间为7 d。给药前、给药后第4天及停药后测定患者的血糖水平。结果:停药后高血糖和血糖升高的发生率,加替沙星组高于左氧氟沙星组(分别为13.91%对6.53%和18.70%对9.80%),差异有统计学意义(P<0.01)。停药后血糖降低的发生率,左氧氟沙星组高于加替沙星组(36.73%对22.17%),差异有统计学意义(P<0.01)。加替沙星组停药后高血糖、血糖升高及降低的发生率,糖尿病患者分别为12.90%、17.74%及22.58%,非糖尿病患者分别为14.29%、19.05%和24.40%,差异无统计学意义(均P>0.05)。结论:加替沙星可致血糖升高或降低,因此临床使用时应予以注意,并应作血糖水平测定。Objective： To study the effects of gatifloxacin on blood glucose in order to provide scientific basis for clinical safe use of the drug. Methods： Four hundred and seventy-five inpatients receiving gatifloxacin or levofloxacin from 13 hospitals between May 2007 and October 2007 were enrolled in a follow-up study, The gatifloxacin group were 230 cases and the levofloxacin group were 245 cases. All patients were administered with an IV infusion of a dose of 400 mg daily for 7 days. Blood glucose levels were measured before drug administration, on day 4 after drug administration, and after drug discontinuation. Results： The incidence of high blood glucose and elevated blood glucose after drug discontinuation were greater in the gatifloxacin group than in the levofloxacin group （ 13.91% vs 6.53% and 18.70% vs 9.80% , respectively）. The differences were statistically significant （P 〈0.01 ）. The incidence of reduced blood glucose after drug discontinuation were greater in the levofloxaein group than the gatifloxacin group （ 36.73% vs 22. 17% ）. The differences were statistically significant （ P 〈 0.01 ）. The incidence of high blood glucose, elevated blood glucose, and reduced blood glucose after drug discontinuation to the gatifloxacin group were 12.90%, 17.74%, and 22.58% in diabetic patients, and 14. 29%, 19. 05%, and 24.40% in non-diabetic patients, respectively. The differences were no statistically significant （all P 〉 0.05）. Conclusion： Gatifloxaein can elevate or reduce blood glucose levels. Therefore, care should be taken and blood glucose levels should be monitored in clinical gatifloxacin use.

关 键 词：加替沙星 左氧氟沙星 血糖 

分 类 号：R96[医药卫生—药理学]