奥沙拉嗪引起肝损害  

Liver damage induced by olsalazine

作　　者：陈海燕[1] 邹传鑫[1] 姚永刚[1] 

机构地区：[1]湖北省荆州市中心医院消化内科,湖北荆州434100

出　　处：《药物不良反应杂志》2008年第4期293-293,共1页Adverse Drug Reactions Journal

摘　　要：1例44岁男性因患溃疡性结肠炎口服奥沙拉嗪治疗。奥沙拉嗪初始剂量为0.5 g,2次/d;之后逐渐增加至1.0 g,3次/d。1个月后,患者出现乏力,食欲减退症状。肝功能检测:ALT 320 U/L,AST 248 U/L,γ-GT 290 U/L,ALP 108.7 U/L,甲、乙、丙、戊型肝炎病毒学检测均阴性。立即停药,给予葡醛内酯口服、甘草酸二铵静脉滴注等治疗。半月后复查肝功能,除AST(68 U/L)外,余项均恢复正常。A 44-year-old man with ulcerative colitis was treated with oral olsalazine. The dosage of olsalazine initially was 0.5 g twice daily, and subsequently was gradually increased to 1.0 g thrice daily. One month later, the man presented with fatigue and anorexia. His liver function tests showed the following： ALT 320 U/L,AST 248 U/L,7-GT 290 U/L,ALP 108.7 U/L. Serologic tests for hepatitis A, B, C, and E were negative. Olsalazine was withdrawn immediately, and he was given oral glueurolaetone and IV diammonium glyeyrrhizinate. After half a month, his liver function normalized except AST （68 U/L）.

关 键 词：奥沙拉嗪 肝损害 不良反应 

分 类 号：R595.3[医药卫生—内科学]