左氧氟沙星注射液致过敏性休克及心跳呼吸骤停  

Anaphylactic shock and cardiorespiratory arrest associated with levofloxacin injection

作　　者：刘建红 张玉锦 荀一飞 丁文 袁玉琴 洪小茜 郭丽霞 丁海燕 

机构地区：[1]解放军第二炮兵后勤部礼士路门诊部,北京100820

出　　处：《药物不良反应杂志》2008年第4期299-299,共1页Adverse Drug Reactions Journal

摘　　要：1例48岁女性,既往有青霉素过敏史,因上呼吸道感染静脉滴注左氧氟沙星注射液0.2 g治疗。首次滴注2 min时,患者出现头晕、恶心、呕吐症状,继之意识丧失,心跳呼吸骤停。立即给予心肺复苏,地塞米松10 mg静注,30 s后患者呼吸、心跳恢复;30 min后,呼吸、心率及血压恢复正常。以后改用阿奇霉素治疗,未再发生类似反应。A 48-year-old woman who had a history of penicilin hypersensitivity was administered with an Ⅳ infusion of levofloxacin 0.2 g for upper respiratory infection. After 2 minutes of this infusion, the woman developed dizziness, nausea and vomiting. Subsequently unconsciousness and cardiorespiratory arrest occurred. She was given cardiopulmonary resuscitation and Ⅳ dexamethasone 10 mg immediately. Thirty seconds later, her breath and heartbeat recovered. Thirty minutes later, her respiration, heart rate, and blood pressure returned to normal limits. The medication was switched to azithromycin and the similar reactions did not reappear.

关 键 词：左氧氟沙星 过敏性休克 心跳呼吸骤停 不良反应 

分 类 号：R593.1[医药卫生—内科学] R595.3[医药卫生—临床医学]