运动疲劳对大鼠海马CAI区神经元电活动的影响  

The Effects of Exercise-Induced Fatigue on Electric Activity of Rats Hippocampus CAI Neurons

作　　者：刘晓莉[1] 杨东升[1] 乔德才[1] 

机构地区：[1]北京师范大学体育与运动学院,北京100875

出　　处：《天津体育学院学报》2008年第4期313-316,共4页Journal of Tianjin University of Sport

基　　金：国家自然科学基金项目(项目编号:30771050);北京市自然科学基金项目(项目编号:5072024)

摘　　要：目的:通过神经电生理学的方法,揭示运动性中枢疲劳的神经生物学机制。方法:30只健康雄性SD大鼠,随机分为安静对照组(CG)、有氧运动组(AG)和运动疲劳组(FG)。采用微电极技术在体观察运动训练后大鼠海马CAI区神经元自发及诱发电活动的变化规律,并通过被动回避行为条件反射的方法观察大鼠的学习记忆能力。结果:FG组大鼠海马神经元的自发和诱发电活动均显著低于CG组和AG组(P<0.05)。FG组学习记忆能力显著低于CG和A(G P<0.05,P<0.01)。结论:运动疲劳可抑制大鼠海马神经元的兴奋性,并降低其学习记忆能力。提示:海马神经元自发放电频率与学习记忆能力有密切关系,运动疲劳导致海马神经元电活动的变化可能是其学习记忆能力降低的机制之一。Objective： The aim of this research is to study the central mechanism of exercise-induced fatigue through the method of neural electrophysiology. Methods： 30 male SD rats were randomly divided into three goups （control group, aerobic exercise group and fatigue group）. The extra cellular records in vivo were made on hippocampus CAI neurons of rats and the ability of learning and memory of rats were measured by a multi-function box for conditioned reflex training passive avoidance measurement, Results： The activity of both spontaneous discharge and evoked discharge decreased significantly in fatigue group （P〈0.05）. The ability of learning and memory of fatigue group was significant lower than control group and aerobic group （P〈0.05, P〈0.01）. Conclusions： The results indicated that exercise-induced fatigue might inhibit the activity of hippocampus neurons and decrease the ability of learning and memory of rats. The effects of exereise-induced fatigue on hippocampus neurons discharge might be one of the mechanisms of depressing the ability of learning and memory.

关 键 词：运动疲劳 海马神经元 电活动 学习记忆能力 

分 类 号：G804.7[文化科学—运动人体科学]