小肠铁释放机制及相关疾病研究进展  

The research for the iron release mechanism and the related disorders in intestinal absorptive cell

作　　者：郭佩[1] 陈伟斌[1] 张洁[1] 常彦忠[1] 段相林[1] 

机构地区：[1]河北师范大学生命科学学院、动物细胞铁代谢研究室,石家庄050016

出　　处：《生命科学》2008年第4期651-656,共6页Chinese Bulletin of Life Sciences

基　　金：河北省自然科学基金(C2006000155)

摘　　要：铁是生物体必需的微量元素。铁缺乏和铁过载均会导致铁代谢紊乱相关疾病,因此有关机体铁水平稳态的调节机制已成为了目前铁代谢领域的研究热点。小肠吸收细胞是调节肠铁吸收、肠铁释放,以及维持机体铁稳态的重要部位。最新的研究表明,铁从小肠吸收细胞基底端释放入血液循环,主要是由膜铁转运蛋白(ferroportinl,Fp1)介导,并在膜铁转运辅助蛋白(haphaestin,Hp)和铜蓝蛋白(ceruloplasmin,Cp)的参与下完成。其中Fp1在小肠铁释放过程中起着至关重要的作用。本文重点阐述铁释放相关蛋白Fp1的作用机制及其调节机制,并详细介绍Fp1基因突变导致的铁代谢相关疾病方面的最新研究进展。Iron is a trace element essential for life. Both iron deficiency and iron overload can lead to iron metabolism disorders. The maintenance mechanism of iron homeostasis has become the hotspot in iron metabolism.Intestinal absorption cell is the key region for iron uptake, iron release and the maintenance of iron homeostasis. Recent study discovered that the release of iron from intestinal absorption cell to the circulation mainly depends on Fp 1 （ferroportin 1）, and also needs the involvement of Hp（haphaestin）and Cp （ceruloplasmin）. This review will put the emphasis on how iron release from intestinal absorption cell and then transfer to the circulation, iron metabolism disorders caused by Fpl, Hp and Cp mutations and the newly research progress of them.

关 键 词：小肠吸收细胞 铁释放 膜铁转运蛋白 HEPCIDIN 铜蓝蛋白 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学] Q584[医药卫生—基础医学]