壳聚糖作为药物缓释控释载体的研究进展  

Research progress of chitosan used as sustained and control drug carrier

作　　者：高娴[1] 马世坤[1] 

机构地区：[1]天津医科大学基础医学院,天津300070

出　　处：《生命科学》2008年第4期657-660,共4页Chinese Bulletin of Life Sciences

基　　金：天津市高等学校科技发展基金(2001YY07)

摘　　要：壳聚糖因其具有良好的生物学特性而成为多种药物载体研究的热点。药物经过壳聚糖负载后,不仅能够达到缓释控释的目的,还能够改变药物的给药方式,以此减少给药次数,降低药物不良反应,提高药物生物利用度。本文就壳聚糖和改性壳聚糖作为普通药物和生物大分子药物载体的研究进展作一综述。As chitosan has very,good properties, the research of chitosan used as sustained and control drug carrier becomes more and more popular. After loaded by chitosan, these drugs can improve their sustained and control release property, alter their drug-administration-pathway. In this way, they can prolong their drugadministration-interval, degrade their adverse reaction and promote their biological availability. This article introduces the research progress of chitosan and modified chitosan used as common drug and biological macromolecular drug carriers.

关 键 词：壳聚糖 药物载体 药物缓释 药物控释 

分 类 号：R318.08[医药卫生—生物医学工程]