基于共轭高分子材料的光学生物传感器  

High Sensitivity Optical Biosensors Based on Conjugated Polymers

作　　者：刘兴奋[1] 王丽华[2] 宋世平[2] 樊春海[1] 黄维[1] 

机构地区：[1]南京邮电大学信息材料与纳米技术研究院 [2]中国科学院上海应用物理研究所,上海201800

出　　处：《化学进展》2008年第9期1375-1384,共10页Progress in Chemistry

基　　金：国家自然科学基金项目(No.20404016、90406021);国家重点基础研究发展计划(973)项目(No.2006CB9330002、007CB936000);上海市科学技术委员会项目(0652nm006、06ZR14106、0752nm021)资助

摘　　要：以聚芴、聚噻吩、聚乙炔为典型代表的共轭导电高分子材料,是作为传感元件进行光、电信号传导的优异材料,目前已成为生物传感器领域研究的热点。基于不同类型、不同性质的共轭高分子所设计的传感策略特色各异,功能也不尽相同,例如:利用共轭高分子可以与某些电子/能量受体之间发生电子/能量转移的特点,可以使传感器的检测信号得到数百万倍的放大,从而极大地提高检测的灵敏度;利用共轭高分子的光学性质随构象变化而变化的特点,则可以实现对靶介导的生物分子的构象或结构转变的检测。本文对各种基于不同传感策略的共轭高分子光学生物传感器研究进行了综述,并对该领域的发展前景进行了展望。Conjugated polymers （ CPs ） characteristics, which can be used as excellent with large, delocalized molecular structures exhibit unique optical sensing elements. Recently, the use of water-soluble CPs as either chemical or biological sensor elements has received intense research interest. The sensing mechanism can be variable with different conjugated polymers used. For example, million-fold signal amplification can be achieved when electron/energy that moves along a conjugated chain is transferred to an appropriate acceptor uhrafastly, so the sensitivity of the biosensor can be improved remarkably. Some CPs＇ optical characteristics can be changed when the conformations of the conjugated backbone or the profile substitutes are changed. With this, the colorimetric and fluorometric biosensors are designed by changing the conformation of the probes mediated by the combination of the specific targets

关 键 词：生物传感器 共轭高分子 光学传感器 

分 类 号：O631.2[理学—高分子化学] TP212.3[理学—化学]