乙型肝炎病毒前S1抗原的研究分析  

Investigation and analysis on HBV pre-S1 antigen

作　　者：王苏平 范建华[2] 

机构地区：[1]南平出入境检验检疫局,南平353000 [2]福建出入境检验检疫局,福州350001

出　　处：《口岸卫生控制》2008年第4期22-23,共2页Port Health Control

摘　　要：目的探讨乙肝病人以乙肝病毒前S1抗原(HBV-PreS1抗原)的检测作为早期诊断乙肝病毒(HBV)感染及其传染性的依据。方法491份样品采用ELISA法做HBV-M、HBV-PreS1抗原及PCR法做HBV-DNA检测,并进行分类计算统计。结果乙肝表面抗原(HBsAg)阳性模式的样品做HBV-PreS1抗原及HBV-DNA检测,两者符合率达90%以上;尤其是急性肝炎两者符合率达97.89%。结论HBV-PreS1抗原检测可用ELISA法,方法直接,操作简单,成本低廉,可作为临床上判断乙肝病毒复制及传染性的新标志。Objective To find a new way for early diagnosis of HBV infecton with Pre-S1 antigen. Methods 491 serum samples were detected for HBV markers and Pre-S1Ag by ELISA , HBV-DNA by PCR, analyze the relationship between Pre-S1Ag and HBV-DNA by statistics. Results To HBsAg positive samples, both Pre-S1Ag and HBV-DNA positive rate were above 90% ; it can reach 97.89% in acute hepatitis cases. Conclusion PreSlAg can be detected by ELISA , simple operation and cheap cost are its specialties, and can be clinically used as a new indicator of HBV reproduction and infectivity

关 键 词：乙肝病毒前S1抗原 HBV—DNA 乙肝两对半 

分 类 号：R512.6[医药卫生—内科学]