幼鼠呼吸道梗阻后前胸壁凹陷畸形  

Anterior Chest Wall Depression Deformity after Airway Obstruction on Juvenile Rats

作　　者：吴学东[1] 周炳昆[1] 李庄[1] 李俊[1] 李爱民[1] 

机构地区：[1]大理学院附属医院,云南大理671000

出　　处：《大理学院学报（综合版）》2008年第8期46-49,共4页Journal of Dali University

基　　金：云南省自然科学基金资助项目(2006C0090M)

摘　　要：目的:探讨呼吸道梗阻后幼鼠胸廓形状的变化。方法:将60只4周龄SD(Sprague Dawley)大鼠随机分成留线组、除线组和对照组,每组20只,用1#慕丝线绕颈段气管外围结扎固定除线组与留线组大鼠气管,术后第1、2、4、8、12周观察胸廓外观变化并于术后第12周行胸部CT扫描,除线组于术后第4周取出气管固定线。各组胸廓外观变化和前胸壁畸形发生率采用χ2检验进行分析。结果:呼吸道梗阻大鼠术后出现前胸壁扁平,留线组和除线组分别有20%(4/20)和25%(5/20)发生前胸壁凹陷畸形,有统计学意义(P<0.01),对照组无发生前胸壁畸形者。结论:呼吸道梗阻能导致生长发育期动物胸廓形状改变,甚至发生前胸壁的漏斗状畸形。Objective： To present the changes of chest wall configuration in rats with airway obstruction. Methods： 60 Sprague Dawley （SD） rats of 4 weeks old were divided into 3 groups at random and there were 20 SD rats in each group respectively. A suture was tied round the trachea after anesthesia in group 1 and 2, no intervene was made in group 3 as the contrast. The tied suture were removed in group ：2 four weeks later. They were fed for twelve weeks and the changes of chest wall configuration were recorded after operation. Data were analyzed with statistics by Chi-square test, Results： The occurrence rate of anterior chest wall depression deformity was 20% in group 1 and 25% in group 2 after operation with airway obstruction but no chest wall malformation took place in group 3. The differentiation was statistically significant （P〈0.01）, Conclusions： The data suggested that the changes of chest wall configuration and even the pectus deformity could be induced by airway obstruction in juvenile rats.

关 键 词：呼吸道梗阻 胸廓形状 漏斗胸 大鼠 

分 类 号：R655.1[医药卫生—外科学]