VDR基因多态性与儿童支气管哮喘的研究进展  

作　　者：王琳[1] 甄艳芬[2] 

机构地区：[1]内蒙古医学院2006级在读研究生,内蒙古呼和浩特010000 [2]中国人民解放军第二五三医院

出　　处：《中国保健》2008年第27期1296-1298,共3页Chinese Health Care

摘　　要：维生素D是一种重要的的免疫调节剂，其活性形式为1，25-（OH）2D3，它与维生素D受体结合后发挥生物学效应。维生素D受体多样性被发现与以T辅助淋巴细胞发展失平衡有关的免疫系统代谢病有关。维生素D受体基因位于12号染色体通常与哮喘有关的区域附近，研究发现维生素D受体具有增强Th2辅助淋巴细胞的作用，是观察哮喘非常好的候选基因。维生素D受体基因多态性在儿童支气管哮喘基因研究中具有重要的价值。The active form of vitamin D, 1,25 - dihydroxyvitamin D3 [ 1,25 - （OH） 2D3 ]. Through interaction with VDR, 1,25 - dihydroxy vitamin D3 mediates numerous biological activities. Variants of the VDR have been found to be associated with immune - mediated diseases that are characterized by an imbalance in helper T -cell development. VDR maps to chromosome 12q,near a region commonly linked to asthma. Vitamin D is an important immune system regulator, The VDR, hence, is a good candidate to be investigated for association with asthma,which is characterized by enhanced helper T - cell type 2 activity. The VDR gene polymorphisms is valuable in the gene research area of children asthma.

关 键 词：维生素D 维生素D受体 基因多态性 儿童 支气管哮喘 

分 类 号：R725.6[医药卫生—儿科;医药卫生—临床医学]