糖类乙酰基和苄基保护新方法的探索  

Improved methods for protection of hydroxyls of carbohydrates using acetyl and benzyl radicals

作　　者：姜宇华[1] 方志杰[1] 焦岩[1] 李洪伟[1] 

机构地区：[1]南京理工大学化工学院,江苏南京210094

出　　处：《化学试剂》2008年第9期691-692,694,共3页Chemical Reagents

摘　　要：以HClO4/SiO2固体酸催化剂对部分单糖和二糖的乙酰化反应条件进行了优化,并用重结晶或萃取方法代替柱层析分离产物。结果表明,该乙酰化方法快速高效,产物容易分离,酸酐的用量较少。还对乙酰化二糖的苄基化反应进行了探索,显著提高了八苄基蔗糖的得率。The process for preparing acetyl protected monosaccharide and disaccharide were optimized using HCIO4/SiO2 as the acetylating catalyst. Instead of using silica column chromatography,recrystallization and extraction were applied to simplify the process for isolation of products. It was found that this process could use less Ac2O with advantages featuring quick reaction rate, high efficiency and environmentally friendly property. Furthermore, several benzyl-protected disaccharides were prepared from peracetyldisaccharides and the yield of octa-benzyl sucrose was improved notably.

关 键 词：高氯酸/二氧化硅 乙酰化 苄基化 固体酸催化 

分 类 号：O629.11[理学—有机化学]