4-异氰酸酯基苯乙酸乙酯的合成工艺研究  

Study on ethyl 2-(4-isocyanatophenyl) acetate production

作　　者：刘剑敏[1] 郭平[1] 叶发青[1] 吴健标[1] 

机构地区：[1]温州医学院药学院,浙江温州325035

出　　处：《化学试剂》2008年第9期707-708,710,共3页Chemical Reagents

基　　金：温州市科技局项目(Y20060240)

摘　　要：介绍了以对氨基苯乙酸乙酯和三光气为原料合成其异氰酸酯的研究。重点讨论了溶剂、原料配比、反应时间、反应温度和滴加顺序等对合成工艺的影响。研究表明：以1,2-二氯乙烷为溶剂,反应回流时间为4~5 h,物质的量比n二（三-氯甲基）碳酸酯（BTC）∶n对氨基苯乙酸乙酯=1∶2,收率可达97%。The preparation of ethyl 2- （4-isocyanatophenyl） acetate production using 4-amino-phenyl ethylacetate and triphosgene as the staring materials was described. The influence of such factors as the solvent, the mole ratio of raw materials, the reaction time and the sequence of materials feeding on the reaction process was studied.The yield could reach 97% using 1,2-dichloroethane as the solvent at a mass ratio of triphosgene to 4-amino-phenyl ethylacerate = 1 ： 2 with refluxing of the reaction mixture for 4 ~ 5 h.

关 键 词：对氨基苯乙酸乙酯 异氰酸酯 二(三氯甲基)碳酸酯 合成 

分 类 号：R969[医药卫生—药理学]