新藤黄酸亲水凝胶骨架片的制备和体外释放度研究  

Study on Neogambogic Acid Sustained-Release Tablets and in Vitro Release Characteristics

作　　者：周晶[1] 王效山[1] 赵煤矿[1] 刘修树[1] 周娟[1] 

机构地区：[1]安徽中医学院药学院,安徽合肥230038

出　　处：《中国药业》2008年第18期22-23,共2页China Pharmaceuticals

摘　　要：目的研究新藤黄酸骨架片体外释药速率的影响因素。方法以羟丙甲基纤维素(HPMC)为骨架材料,考察HPMC用量、乙基纤维素(EC)用量、乳糖用量、压片压力和桨转速对药物体外释药行为的影响。结果HPMC和EC用量显著影响新藤黄酸的释药速率,乳糖用量、压片压力和桨转速的影响较小。结论通过调节HPMC和EC用量可获得具有理想释药行为的新藤黄酸亲水凝胶缓释片。Objective To study the influential factors of the release rate of neogambogic acid from sustained release matrix tablets. Methods The influence of formulation and process variances such as the amount of HPMC, EC, lactose, compression force and rotation speed of pad- dle were investigated. Results The rate of neogambogic acid release was mainly controlled by the amount of HPMC and EC. The effects of the amount of lactose, compression force and rotation speed of paddle on the drug release were not significant. Conclusion Adjusting the amount of HPMC and EC,the neogambogic acid sustained release tablet with ideal release behavior is obtained.

关 键 词：新藤黄酸 缓释 体外释放度 

分 类 号：TQ461[化学工程—制药化工]