多巴胺对家兔肾血流量的量效关系  

DoseEffect Relationship between Dopamine and Renal Blood Flow in Rabbits

作　　者：王清[1] 张志鉴[1] 宋运琴[1] 

机构地区：[1]解放军总医院麻醉科

出　　处：《临床麻醉学杂志》1997年第6期325-327,共3页Journal of Clinical Anesthesiology

摘　　要：目的和方法：比较静脉恒速滴注２、５、１０、２０μｇｋｇ－１ｍｉｎ－１不同剂量多巴胺对家兔肾血流量（ＲＢＦ）、尿量及一些循环功能指标的影响。结果：２及５μｇ组ＲＢＦ明显增加，１０μｇ组轻度增加，２０μｇ组显著降低（Ｐ＜０．０１）。尿量随ＲＢＦ增加而增多。ＭＡＰ在１０μｇ以下的两组呈上升趋势，２０μｇ组无变化。ＨＲ在各剂量组均增快，以２μｇ组显著。２０μｇ组多数出现室性心律失常，其余各组未发生。结论：抗休克应用多巴胺时，剂量最好勿大于１０μｇｋｇ－１ｍｉｎ－１，否则不利于肾功能的维护。Objective and Methods:The influences of dopamine (DA) on rental blood flow (RBF),urine outpwt,ECG and hemodynamics under continuous infusion of different doses of 2,5,10and 20μg·kg-1·min-1 DA were studied in 30 rabbits.Results:RBF increased significantly following infusion of dopamine in a dose of or 5μg·kg-1·min-1 and slightly in a dose of 10μg·kg-1·min-1 was infused.On the contrary,the RBF decreased markedly when DA 20μg·kg-1·min-1 was infused.Urine output changed in correspondence with RBF and increased grandually during dopamine infusion in lower dosage,but no change in a dose of 20μg·kg-1·min-1.HR,however increased significantly in all dose groups.Ventricular arrhythmia occured only in the 20μg·kg-1·min-1 dose group.Conclusion:For treatment of shock,the dose of dopamine should not exceed 10μg·kg-1·min-1,because higher doses of dopamine may lead the outcome even worse.

关 键 词：多巴胺 肾血流量 剂量 

分 类 号：R971.93[医药卫生—药品]