系统性红斑狼疮患者血清中α干扰素和白介素6、10与临床及免疫学指标相关性研究  

The relationship between serum level of IFN-α,IL-6,IL-10 and disease activity in the patients with systemic lupus erythematosus

作　　者：顾镭[1] 张戎[2] 王慧娟[2] 杨晓帆[2] 张缪佳[1] 沈友轩[1] 季晓辉[2] 

机构地区：[1]南京医科大学第一附属医院风湿科,江苏南京210029 [2]南京医科大学微生物免疫学系,江苏南京210029

出　　处：《临床皮肤科杂志》2008年第9期578-580,共3页Journal of Clinical Dermatology

基　　金：江苏省自然科学基金资助项目(BK2004148)

摘　　要：目的:通过对系统性红斑狼疮(SLE)患者血清中异常表达的干扰素(IFN)-α、白介素(IL)-6、IL-10与多种临床与免疫学指标相关性研究,为探讨该细胞因子在SLE免疫紊乱中的作用奠定基础。方法:选择50例SLE患者,采用ELISA法测定血清中IFN-α、IL-6、IL-10水平,并分析其与SLE临床与免疫学指标的相关性。结果:①SLE患者血清中IL-6、IL-10水平均显著高于正常对照组,差异具有统计学意义。②SLE患者血清中IFN-α、IL-6、IL-10水平与SLE疾病活动度指数(SLEDAI)均呈正相关。③SLE患者血清中IFN-α、IL-6、IL-10水平与某些临床表现及免疫学指标具有相关性。结论:SLE患者血清中存在的多种细胞因子异常,对SLE的发生、发展、表现、转归及指导治疗都具有十分重要的意义。Objective： To investigate the pathogenesis of cytokines in systemic lupus erythematosus （SLE） through evaluating the relationship between the serum levels of them and the disease activity. Methods： Fifty cases of active SLE were studied. Their serum levels of IFN-α,IL-6,IL-10 were measured by ELISA assay, their clinical manifestations and other immunologic findings were recorded to evaluate the disease activitives. Results： ① The serum levels of IL-6,IL-10 in SLE patients increased significantly as compared with those in normal controls. ②There was a positive correlation between serum levels of IFN-α,IL-6,IL-10 and the disease activity （SLEDAI） in SLE patients. ③There was a positive correlation between the serum levels of IFN-α,IL-6,IL-10 and the clinical manifestations and immunologic findings in SLE patients. Conclusion： The abnormally increased cytokines in SLE patients may have important significance in recognizing the pathogenesis and the treatment of SLE.

关 键 词：红斑狼疮 系统性 Α干扰素 白介素-6 白介素-10 临床表现 

分 类 号：R593.241[医药卫生—内科学]