大鼠延髓网状背侧亚核内μ阿片肽受体和脑啡肽免疫阳性神经元的分布  

DISTRIBUTION OF μ-OPIOID RECEPTOR AND ENKEPHALIN IMMUNOREACTIVE NEURONS IN SUBNUCLEUS RETICULARIS DORSALIS OF THE RAT

作　　者：凌树才[1,2] 李云庆[1,2] 施际武 

机构地区：[1]南通医学院神经生物学研究室 [2]第四军医大学解剖学教研室

出　　处：《南通医学院学报》1997年第4期443-445,448,共4页ACTA Academiae Medicinae Nantong

基　　金：江苏省自然科学基金

摘　　要：用免疫组织化学ＡＢＣ法研究正常大鼠延髓网状背侧亚核（ＳＲＤ）内的μ阿片肽受体（ＭＯＲ）、Ｌ－ＥＮＫ和Ｍ－ＥＮＫ阳性结构的分布。结果显示：（１）该核内有较丰富的ＭＯＲ阳性胞体和树突样结构分布；（２）ＳＲＤ内Ｌ－ＥＮＫ阳性胞体的分布密度为中等，主要由中小型的神经元构成，并见有较多的Ｌ－ＥＮＫ阳性终末；（３）ＳＲＤ内Ｍ－ＥＮＫ阳性终末的分布很密集，偶见少量胞体。上述结果说明和ＥＮＫ在该核内的分布是相互匹配的，提示ＳＲＤ是内源性阿片肽的作用靶区。另对ＳＲＤ神经元内上述物质的功能和意义进行讨论。The immunohistochemical method was used in the present study to localize the μ-opioid receptor (MOR), L-ENK and M- ENK in the rat subnucleus reticularis dorsalis (SRD). The results as follows: (1) More MOR like immunoreactive (LI) cell bodies and dendrites were fonud in SRD. (2) A moderate density of L-ENK- LI somata and terminals were detected in SRD.(3) A large number of M-ENK-LI terminals were observed. Occasionally, sparse M-ENK-LI cell body were seen in SRD. The results indicat that the MOR-LI positive neurons and ENK-LI positive terminals had an overlapping distribution.It suggested that SRDneurons is one of the targets for the action of the endogenous opioid in the brain. The functional significance of those substance in SRD was also discussed.

关 键 词：延髓 网状背侧亚核 阿片肽 受体 脑啡肽 

分 类 号：R329.481[医药卫生—人体解剖和组织胚胎学]