冠状动脉支架置入术后多形核白细胞活化的相关分子的表达  

Polymorphonuclear neutrophil markers of activation after percutaneous coronary stenting in patients with unstable angina

作　　者：夏思良[1] 周建松[1] 郭振峰[1] 颜京瑞[1] 

机构地区：[1]东南大学附属南京江北人民医院心内科,南京210048

出　　处：《临床心血管病杂志》2008年第8期583-585,共3页Journal of Clinical Cardiology

基　　金：南京市医学科技发展项目(No:320.2410)

摘　　要：目的：探讨冠状动脉支架置入术后多形核白细胞（PMN）活化的相关分子的表达。方法：选择18例不稳定型心绞痛患者，在冠状动脉支架置入前（T0）和置入后30min、3h、6h、12h、24h（分别为T1～T5）用ELISA法测定血白细胞介素-8（IL-8）、髓过氧化物酶（MPO）、L-选择素（L-selectin）、超敏C反应蛋白（hsCRP）浓度。结果：支架组T1～T5各时段的PMN相关分子IL-8、MPO、Lselectin、hs-CRP表达增加，它们分别在支架置入后3h、30min、12h、24h达高峰，同T0比较差异有统计学意义（P〈0．01）。结论：冠状动脉支架置入术后IL-8、MPO、L-selectin、hsCRP表达增加，触发PMN的聚集和局部的炎症反应。Objective：The aim of the study was to determine the presense of Polymorphyonuclear neutrophils （PMN）activation after coronary stenting in patients with unstable angina. Method.. Plasma levels of IL-8, myeloperoxidase（MPO）, high-sensitivity C reactive protein（hs CRP） and L-selectin were assayed in 18 patients undergoing percutaneous coronary stenting （group A）and compared with 7 patients undergoing coronay angiography only（group B）. Serial sampling starting before stenting and continued for 24 h was carried out in all patients. Result： A significant elevation in IL-8 , MPO, L-selectin, hs-CRP were observed after stenting in 3 h, 30 min, 12 h, 24 h（P〈0.01）. Conclusion：Coronary stenting is associated with an immediate polymorphonuclear neutrophils activation followed by release of inflammtory cytokine.

关 键 词：血管成形术 经腔 经皮冠状动脉 多形核白细胞 白细胞介素-8 髓过氧化物酶 L-选择素 

分 类 号：R654.3[医药卫生—外科学]