瘦素对人脐静脉内皮细胞表达白细胞介素-8的影响  

Expression of interleukin-8 induced by leptin in ECV-304 cells

作　　者：王绪明[1] 侯巧燕[1] 陆明深[1] 陈峰[1] 张美艳[1] 曾思恩[1] 周英琼[1] 韦华生[1] 

机构地区：[1]桂林医学院病理学教研室,广西桂林541001

出　　处：《临床心血管病杂志》2008年第8期598-600,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨瘦素对人脐静脉内皮细胞(ECV-304)表达白细胞介素-8(IL-8)的影响。方法:用不同浓度的瘦素刺激ECV-304,检测ECV-304表达IL-8的情况。结果:在相同作用时间下,随着瘦素浓度的升高,IL-8蛋白及IL-8的mRNA的表达也随之升高;在相同瘦素浓度下,随着作用时间的延长,IL-8蛋白及IL-8的mRNA的表达也随之升高。结论:瘦素可以刺激ECV-304表达IL-8,而且呈时间和剂量相关性。Objective： To investigate the effect of leptin on the expression of IL-8 induced by ECV-304. Method：We used the leptin with different concentration to stimulate the primary culture ECV-304. Then the expression of IL-8 induced by ECV-304 was detected. Result： In the same action time, the expression of IL-8 protein and IL- 8 mRNA improved when the level of leptin improved; meanwhile, in the same concentration of leptin, the expression of IL-8 prot.ein and IL-8 mRNA improved when the action time extended. Both were significant when they were analyzed by the statistics. Conclusion.. The expression of IL-8 induced by ECV-304 is correlated positively with the level of leptin and it＇s action time.

关 键 词：动脉粥样硬化 瘦素 白细胞介素-8 

分 类 号：R543.5[医药卫生—心血管疾病]