新疆哈萨克族人群中血管紧张素Ⅱ-1型受体基因多态性与原发性高血压的相关性研究  

Study for relationship between the angiotensin Ⅱ type 1 receptor gene polymorphism and essential hypertension in Kazakans of Xinjiang

作　　者：李涛[1] 李南方[1] 周玲[1] 王新玲[1] 祖菲亚[1] 王君[1] 张德莲[1] 周克明[1] 

机构地区：[1]新疆高血压研究所新疆维吾尔自治区人民医院高血压科,乌鲁木齐830001

出　　处：《临床心血管病杂志》2008年第8期606-608,共3页Journal of Clinical Cardiology

基　　金：国家自然科学基金资助项目(No:30260038)

摘　　要：目的:研究血管紧张素Ⅱ-1型受体(AT1R)基因A1166C多态性与新疆哈萨克族原发性高血压(EH)的相关关系。方法:采用多聚酶链式反应法及限制性片段长度多态性技术(PCR-RFLP),对新疆哈萨克族321例EH患者(EH组)及203例正常血压者(对照组)的外周血白细胞DNA,进行AT1R基因A1166C多态性检测,统计分析该位点不同基因型及等位基因频率在EH组和对照组中的分布。结果:AA、AC和CC基因型在EH组的分布频率为0.7664、0.2274和0.0062,在对照组中分别为0.7537、0.2463和0,2组对比差异无统计学意义(P>0.05);A1166与1166C等位基因频率在EH组中分别为0.8801、0.1199,在对照组中分别为0.8768和0.1232,2组相比差异也无统计学意义(P>0.05)。结论:AT1R基因A1166C多态位点分子变异与新疆哈萨克族EH易感可能不相关。Objective：To investigate the relationship between the A1166C allele polymorphism of angiotensin Ⅱ type 1 receptor （AT1 R） gene and the essential hypertension in Kazakans of Xinjiang. Method：Polymerase chain reaction and restriction fragment length polymorphism methods （PCR-RFLP） were used to detect the A1166C polymorphism of AT1 R gene in Kazakans including 321 patients with hypertension and 203 normotensive controls. The frequencies of genotype distribution in hypertensives and normotensives were studied. Result： The genotype frequencies of A1166C were AA 0. 766 4, AC 0. 227 4,CC 0. 006 2 in the hypertension group and the corresponding frequencies were 0. 753 7,0. 246 3, 0, in the control group respectively; The A1166 and 1166C allele frequencies were 0. 880 1,0. 119 9 respectively in hypertension group and 0. 876 8,0. 123 2 in normotensive group. The distribution of A1166C-genotype and the allele frequencies of A1166/1166C were not statistic significances in hypertension group compared with normotensive group （P〉 0. 05）. Conclusion： There was no significant association found between the A1166C polymorphism of AT1 R gene and essential hypertension in Kazakans of Xinjiang.

关 键 词：高血压 血管紧张素Ⅱ-1型受体 A1166C多态性 哈萨克族 

分 类 号：R544.1[医药卫生—心血管疾病]