神经生长因子对心肌梗死后大鼠肾上腺素能神经的影响  

Effect of nerve growth factor on adrenergic nerve in rats after myocardial infarction

作　　者：倪秀芹[1] 李星[2] 冯佳[3] 赵玲辉[4] 纪长伟[1] 

机构地区：[1]哈尔滨医科大学大庆校区基础部,黑龙江省大庆市163319 [2]哈尔滨医科大学附属第五医院 [3]佳木斯大学医学院 [4]哈尔滨医科大学

出　　处：《中国综合临床》2008年第10期991-993,共3页Clinical Medicine of China

基　　金：黑龙江省教育厅课题（11511241）;黑龙江省卫生厅课题（2006-312）

摘　　要：目的探讨神经生长因子对心肌梗死后大鼠肾上腺素能神经纤维的保护作用及其机制。方法实验用Wister大鼠120只，分为假手术对照组、心肌梗死模型组、神经生长因子组。分别于术后6h及2、4、7、14d取材，以免疫组织化学方法显示肾上腺素能神经纤维，应用多功能真彩色病理图像分析系统分析肾上腺素能神经纤维的密度。结果①心肌梗死组心肌梗死区及梗死周围区肾上腺素能神经纤维密度在术后6h及2、4、7、14d均低于假手术组。②神经生长因子组术后7、14d心肌梗死区及梗死周围区肾上腺素能神经纤维密度较心肌梗死组明显升高。结论神经生长因子对大鼠急性心肌梗死后心肌肾上腺素能神经具有神经保护作用。Objective To confirm the protective effect of nerve growth factor （ NGF） on cardiac adrenergic nerve in rats after acute myocardial infarction（ AMI） and its mechanism. Methods 120 Wister rats were divided into sham-operated group,AMI group and NGF group. The samples were taken after 6 h,2 d,4 d,7 d and 14 d separately. Immunohistochemistry method was used to show the distribution of adrenergic nerve fibers, The density of them were calculated by Medical Pathological hnage Analysis Processing System. Results ①The densities of adrenerglc nerve fibers in AMI group were obviously lower than that of sham-operated group greatly in 6 h and 2 d,4 d,7 d and 14 d later.②The densities of adrenergic innervation in NGF group were obviously higher than that of AMI group 7 d and 14 d later. Conclusion NGF has protection effect on cardiac adrenergic nerve after AMI in the rat.

关 键 词：心肌梗死 神经生长因子 肾上腺素能神经 

分 类 号：R542.22[医药卫生—心血管疾病]