空心胶囊对溶出度测定的影响  

Impact of vacant capsules on dissolution determination

作　　者：徐燕[1] 杨蕾[1] 刘峰[1] 张罗红[1] 徐晓霞[1] 谢华[1] 

机构地区：[1]四川省食品药品检验所,成都610036

出　　处：《四川生理科学杂志》2008年第3期118-119,共2页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨药物的胶囊剂在应用紫外-可见分光光度法进行溶出度测定时,其空心胶囊对被测主药成分的定量结果的影响。方法:采用紫外-可见分光光度法,氟康唑胶囊(规格:50 mg)的溶出度进行测定。结果:本方法中的空心胶囊的吸光度值,可以导致所测得的溶出度结果平均虚高约20%左右。结论:空心胶囊有可能对溶出度测定中样品的数据造成很大影响,最终影响到对样品溶出度测定结果的评判。Objective： To discuss the impact of vacant capsules on the quantitive determination of main drug in capsules while assaying dissolution by UV-spectrophotometry. Method, The dissolution of fluconazol capsules was determinated by UV-spectrophotometry. Results： The absorbance of the vacant capsules in this method can lead to the value of the calculated dissolution 20% higher than the value of the average. Conclusion： Vacant capsules may greatly impact the value of dissolution of sample, and finally impact the judgment to dissolution results of samples.

关 键 词：空心胶囊 溶出度 紫外-可见分光光度法 

分 类 号：R927[医药卫生—药学]