雄激素对衰老大鼠阴茎组织转化生长因子β基因表达的影响  

Effects of testosterone on the expression of TGF-β mRNA in the penile tissue of castrated rats

作　　者：胡海翔[1] 马建伟[2] 董静[2] 马新英[2] 

机构地区：[1]空军总医院男科门诊,北京100036 [2]空军总医院中医科,北京100036

出　　处：《空军总医院学报》2008年第1期19-21,共3页Journal of General Hospital of Air Force,PLA

摘　　要：目的探讨雄激素对阴茎组织中TGF-β mRNA的调控作用。方法将30只雄性大鼠随机分为3组,衰老组、丙酸睾酮组与对照组(2个月龄大鼠),其中丙酸睾酮组给予丙酸睾酮治疗,于24 d取阴茎组织,用PCR检测其TGF-β mRNA的表达。结果衰老组TGF-β mRNA的表达较其他2组增强,而表现TGF-β mRNA减弱的组,由少到多依次排定为对照组、丙酸睾酮组及衰老组;对照组、丙酸睾酮组及衰老组其TGF-β mRNA内控量较少,与衰老组比较有显著性差异(P<0.01)。结论雄激素可能通过调节TGF-β mRNA表达而在阴茎勃起中发挥重要作用。Objective To investigate whether TGF-βmRNA is associated with testosterone（T） in penile erection. Methods Thirty mature male rats were randomly divided into 3 groups：unoperated controls, castrates,castrates given T replacement. Three weeks after castration, TGF-βmRNA in the penile tissue were detected with PCR technique. Results Compared with control,castrates given T replacement,the TGF-βmRNA in castrates strong which in terms of the extent of TGF-βmRNA,there was such a sequence.. castrates given T replacement〉control;and the in ternally controlled amounts of TGF-βmRNA in the penile tissue,control,castrates given T replacement were significant lower than castrates（P〈0.01）. Conclusion It was suggested that T plays an important role in penile erection through regulating TGF-βmRNA.

关 键 词：转化生长因子β 阴茎 雄激素类 大鼠 

分 类 号：R349.6[医药卫生—基础医学]