Glyoxylic acid as catalyst:A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media  

作　　者：Shivaji S.Pawar Deepak V.Dekhane Murlidhar S.Shingare Shivaji N.Thore 

机构地区：[1]Department of Chemistry,Vinyakrao Patil Mahavidyala Vaijapur,Aurangabad 423701(M.S.),India [2]Department of Chemistry,Dr.Babasaheb Ambedkar Marathwada University,Aurangabad 431004(M.S.),India

出　　处：《Chinese Chemical Letters》2008年第9期1055-1058,共4页中国化学快报（英文版）

基　　金：Head,Department of Chemistry,Vinayakrao Patil Mahavidyala Vaijapur 423701(M.S.),India,for partial support of this work.

摘　　要：Glyoxylic acid （5 mol%） performs as a novel highly water-soluble catalyst for the synthesis of 2-aryl-l-arylmethyl-lH- benzimidazoles from a wide range of substituted o-phenylenediamines and various substituted aldehydes in good to excellent isolated yields （85-95%） using water as solvent at ambient temperature. The remarkable advantages offered by this method are easily and inexpensive available catalyst, simple procedure, mild conditions, much faster （20--40 rain） reactions and excellent yields of products.Glyoxylic acid （5 mol%） performs as a novel highly water-soluble catalyst for the synthesis of 2-aryl-l-arylmethyl-lH- benzimidazoles from a wide range of substituted o-phenylenediamines and various substituted aldehydes in good to excellent isolated yields （85-95%） using water as solvent at ambient temperature. The remarkable advantages offered by this method are easily and inexpensive available catalyst, simple procedure, mild conditions, much faster （20--40 rain） reactions and excellent yields of products.

关 键 词：Glyoxylic acid BENZIMIDAZOLES Aqueous media 2-Aryl-l-arylmethyl-lH-benzimidazoles o-Phenylenediamines and aldehydes 

分 类 号：O626[理学—有机化学]