Synthesis of protected (2S,4R)-2-amino-4-methyldecanoic acid, a proposed component of culicinins  

作　　者：Wei Zhang Tian Tian Sun Duo Mei Jun Fei Wang Ying Xia Li 

机构地区：[1]Key laboratory of Marine Drugs, The Ministry of Education of China, School of Pharmacy, Ocean University of China, Qingdao 266003, China

出　　处：《Chinese Chemical Letters》2008年第9期1068-1070,共3页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.30572245);Hi-Tech Research and Development Program of China(863 program,No.2006AA09Z409);The Excellent Young Scientists Foundation of Shandong Province(No.2006BS02013).

摘　　要：The protected （2S,4R）-2-amino-4-methyldecanoic acid, a proposed component of culicinins has been synthesized over 10 steps and in total 28% yields using Wittig reaction and Schollkopf amino acid synthesis as key steps.The protected （2S,4R）-2-amino-4-methyldecanoic acid, a proposed component of culicinins has been synthesized over 10 steps and in total 28% yields using Wittig reaction and Schollkopf amino acid synthesis as key steps.

关 键 词：SYNTHESIS Amino acid Schollkopf methodology Culicinins 

分 类 号：O62[理学—有机化学] Q516[理学—化学]